{"id":"W2075743517","doi":"10.1503/jpn.100098","title":"The well of novel antidepressants: running dry","year":2010,"lang":"en","type":"editorial","venue":"Journal of Psychiatry and Neuroscience","topic":"Treatment of Major Depression","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Agomelatine; Antidepressant; Melatonin; Agonist; Serotonin; Antagonist; Pharmacology; Medicine; Internal medicine; Receptor; Hippocampus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007360692,0.003248308,0.003859523,0.002681231,0.002817622,0.007470604,0.002442763,0.01014545,0.02115401],"category_scores_gemma":[0.03073956,0.001074102,0.001806388,0.001310939,0.002801472,0.007984322,0.001608951,0.01856569,0.01398397],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001728444,"about_ca_system_score_gemma":0.002790756,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009163962,"about_ca_topic_score_gemma":0.002757209,"domain_scores_codex":[0.9954889,0.0009929978,0.0006996724,0.0004914899,0.00211029,0.0002165197],"domain_scores_gemma":[0.9708319,0.01233991,0.001774931,0.0007776552,0.01124607,0.003029456],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000509376,0.00001524902,0.00002178727,0.0003568743,0.00001889839,0.00006693693,0.00001453191,0.00001560503,0.00006503622,0.0004921928,0.9864792,0.01240272],"study_design_scores_gemma":[0.0000517716,0.00003997674,0.0001512469,0.0006653713,0.00003725307,0.0002399272,0.00005038139,0.00006144126,0.00007876509,0.00100855,0.9975985,0.00001671787],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"editorial","genre_gemma":"editorial","genre_scores_codex":[0.00003661931,0.01188519,0.0001110811,0.03421451,0.9522709,0.00001447762,0.00004165006,0.00005451601,0.001371047],"genre_scores_gemma":[0.000407961,0.01129744,0.0001473943,0.02799966,0.9537863,0.00001459588,0.00003283008,0.00004037799,0.006273369],"genre_candidate":"editorial","genre_consensus":"editorial","teacher_disagreement_score":0.02115401,"threshold_uncertainty_score":0.07076722,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0130551917126342,"score_gpt":0.2998844423825566,"score_spread":0.2868292506699224,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}