{"id":"W2075743517","doi":"10.1503/jpn.100098","title":"The well of novel antidepressants: running dry","year":2010,"lang":"en","type":"editorial","venue":"Journal of Psychiatry and Neuroscience","topic":"Treatment of Major Depression","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Agomelatine; Antidepressant; Melatonin; Agonist; Serotonin; Antagonist; Pharmacology; Medicine; Internal medicine; Receptor; Hippocampus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007165786,0.0002112989,0.0004627785,0.0001517834,0.000245617,0.0000614403,0.0004373001,0.0003231009,0.000004980789],"category_scores_gemma":[0.0008982249,0.0001179109,0.0001831702,0.0001724314,0.0004123647,0.000184708,0.00009868933,0.001613621,6.219012e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001063189,"about_ca_system_score_gemma":0.000608611,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006097213,"about_ca_topic_score_gemma":0.000006148146,"domain_scores_codex":[0.997658,0.00003389685,0.0006460436,0.0002641819,0.001174378,0.0002235386],"domain_scores_gemma":[0.9975101,0.0004195963,0.001287913,0.000362683,0.0002446461,0.0001750877],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0009981808,0.001001965,0.03314093,0.0003203134,0.00004485996,0.00007019655,0.00004734328,0.0000119934,0.0869479,0.00007459477,0.8759631,0.001378635],"study_design_scores_gemma":[0.004550502,0.002226216,0.04266107,0.002164178,0.0004798245,0.0004315652,0.00005404943,0.0001124682,0.002807375,0.0001429029,0.9441417,0.0002280716],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"editorial","genre_gemma":"editorial","genre_scores_codex":[0.05079385,0.003391949,0.00008364567,0.001193512,0.9439265,0.0001411888,0.00001829703,0.000008633188,0.000442417],"genre_scores_gemma":[0.06443419,0.0113349,0.006996128,0.0003125681,0.9148043,0.000003244198,0.000003948612,0.00008315018,0.002027552],"genre_candidate":"editorial","genre_consensus":"editorial","teacher_disagreement_score":0.08414052,"threshold_uncertainty_score":0.7010469,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0130551917126342,"score_gpt":0.2998844423825566,"score_spread":0.2868292506699224,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}