{"id":"W2075799410","doi":"10.1016/j.bbalip.2012.10.009","title":"Macrophage heterogeneity and cholesterol homeostasis: Classically-activated macrophages are associated with reduced cholesterol accumulation following treatment with oxidized LDL","year":2012,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids","topic":"Atherosclerosis and Cardiovascular Diseases","field":"Immunology and Microbiology","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Paul's Hospital","funders":"Canadian Institutes of Health Research; Pfizer Canada; Mitacs; Pfizer","keywords":"CD36; Foam cell; Scavenger receptor; Macrophage; Tumor necrosis factor alpha; Cholesterol; Monocyte; Receptor; Chemistry; Endocrinology; Internal medicine; Cell biology; Biology; Lipoprotein; Immunology; Biochemistry; Medicine; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001803693,0.0005757039,0.0009336406,0.0001126061,0.0002261617,0.00004461017,0.0001795518,0.0004457011,0.000007531873],"category_scores_gemma":[0.00001786181,0.0004090732,0.0003438719,0.0001999956,0.0006026133,0.000166361,0.0001174988,0.000227554,0.000004091682],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004362784,"about_ca_system_score_gemma":0.0000487734,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004150179,"about_ca_topic_score_gemma":0.000007335286,"domain_scores_codex":[0.9974868,0.0007379735,0.0003813008,0.0006876344,0.00009271297,0.0006136193],"domain_scores_gemma":[0.9987847,0.0001007899,0.000425281,0.0004865147,0.00005930409,0.0001434371],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000581797,0.0007613796,0.002881757,0.00003505779,0.002122926,0.000003282138,0.0002622259,0.000001841457,0.9915695,0.000005906147,0.00000524785,0.001769101],"study_design_scores_gemma":[0.004918538,0.001243518,0.1351775,0.0001125454,0.0008533415,0.00001259844,0.0001468606,0.000002924564,0.8570427,0.000003437154,0.00008356857,0.0004024411],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943249,0.004501145,0.00007765123,0.0001299784,0.0001206057,0.0005624556,0.0001586503,0.00008340395,0.00004123949],"genre_scores_gemma":[0.998549,0.0005638267,0.00009256702,0.0001642224,0.00003658737,0.00008213624,0.0004204678,0.00006403171,0.00002710745],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1345268,"threshold_uncertainty_score":0.9998361,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01694052099978172,"score_gpt":0.2505235481025834,"score_spread":0.2335830271028017,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}