{"id":"W2075825598","doi":"10.1016/j.tibtech.2005.05.001","title":"Silencing nature's narcotics: metabolic engineering of the opium poppy","year":2005,"lang":"en","type":"article","venue":"Trends in biotechnology","topic":"Berberine and alkaloids research","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"Plant Biotechnology Institute","funders":"","keywords":"Opium Poppy; Papaver; Poppy; Opium; Thebaine; Narcotic; Metabolic engineering; Metabolic pathway; Morphine; Gene silencing; Chemistry; Biology; Pharmacology; Codeine; Botany; Gene; Biochemistry; Medicine; Political science; Anesthesia; Law","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001727448,0.0001143485,0.0002809319,0.0006426342,0.00002086864,0.000003007396,0.0002682413,0.000455082,0.0001233256],"category_scores_gemma":[0.0001690864,0.00007963679,0.00008475446,0.001099407,0.0001245388,0.00003197046,0.0001733586,0.001086622,0.00001050412],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004582523,"about_ca_system_score_gemma":0.00003258166,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004953163,"about_ca_topic_score_gemma":0.0000713466,"domain_scores_codex":[0.9990647,0.00001868103,0.0002315664,0.0001915458,0.0001760421,0.0003174877],"domain_scores_gemma":[0.9993848,0.00003553019,0.00004102241,0.0004760471,0.00002733691,0.00003528124],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004545235,0.0002227811,0.007967858,0.00007556834,0.00008939496,0.00002974743,0.0001983189,0.0002810039,0.5670144,0.02266155,0.0007487087,0.4006652],"study_design_scores_gemma":[0.0009160584,0.00009997746,0.03838444,0.00008671324,0.00002742163,0.0001106537,0.00006769444,0.002859181,0.8962774,0.00005943153,0.06098993,0.0001211497],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9758445,0.002676114,0.00003763626,0.0193189,0.0001288899,0.00009165087,0.00000364534,0.00009616811,0.001802464],"genre_scores_gemma":[0.9958978,0.0002182704,0.002679052,0.0001551982,0.0001075943,0.000007056818,0.000002472998,0.0000167048,0.0009158202],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.400544,"threshold_uncertainty_score":0.4720892,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01111503313265353,"score_gpt":0.297245544044432,"score_spread":0.2861305109117784,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}