{"id":"W2075825598","doi":"10.1016/j.tibtech.2005.05.001","title":"Silencing nature's narcotics: metabolic engineering of the opium poppy","year":2005,"lang":"en","type":"article","venue":"Trends in biotechnology","topic":"Berberine and alkaloids research","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"Plant Biotechnology Institute","funders":"","keywords":"Opium Poppy; Papaver; Poppy; Opium; Thebaine; Narcotic; Metabolic engineering; Metabolic pathway; Morphine; Gene silencing; Chemistry; Biology; Pharmacology; Codeine; Botany; Gene; Biochemistry; Medicine; Political science; Anesthesia; Law","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001018782,0.0003793692,0.0002611096,0.0001492193,0.0001797978,0.0004546965,0.0002247978,0.0002564462,0.0006202467],"category_scores_gemma":[0.0001080071,0.0001376192,0.0003671341,0.0001715028,0.0002064695,0.0002064998,0.0003083707,0.0006998065,0.0002187708],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002639928,"about_ca_system_score_gemma":0.0002518734,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008023324,"about_ca_topic_score_gemma":0.001334212,"domain_scores_codex":[0.9999313,0.000008944943,0.000004305466,0.00001296986,0.00002529066,0.00001718172],"domain_scores_gemma":[0.9999408,0.00001444929,0.00001973568,0.000007106905,0.000005778148,0.00001222171],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003285715,0.000009813733,0.00006226319,0.00001974086,0.000006139421,0.00004211612,0.00001219513,0.000157908,0.9980117,0.0002349172,0.00002204675,0.001388253],"study_design_scores_gemma":[0.000007924057,0.00009524275,0.001348692,0.000005589186,0.00002727991,0.0001900184,0.00003908058,0.001817691,0.9910815,0.0001905003,0.005189024,0.000007397404],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9773638,0.000843848,0.01754031,0.0004635869,0.00005435419,0.00004070285,0.0003985313,0.0001759838,0.003118837],"genre_scores_gemma":[0.9804651,0.001238232,0.01090275,0.00008761489,0.000008483472,0.00002098516,0.0004499999,0.0001047095,0.006722106],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008023324,"threshold_uncertainty_score":0.002074957,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01111503313265353,"score_gpt":0.297245544044432,"score_spread":0.2861305109117784,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}