{"id":"W2075828741","doi":"10.1021/bi9016457","title":"New Glucosidase Inhibitors from an Ayurvedic Herbal Treatment for Type 2 Diabetes: Structures and Inhibition of Human Intestinal Maltase-Glucoamylase with Compounds from <i>Salacia reticulata</i>","year":2009,"lang":"en","type":"article","venue":"Biochemistry","topic":"Enzyme Production and Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":184,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; University of Waterloo; University of Toronto; Ontario Institute for Cancer Research","funders":"National Center for Research Resources; Canadian Institutes of Health Research","keywords":"Acarbose; Maltase; Alpha-glucosidase; Glycoside hydrolase; Chemistry; Glucosidases; Enzyme; Sucrase; Biochemistry; Type 2 diabetes; Pharmacology; Hydrolysis; Traditional medicine; Diabetes mellitus; Medicine; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005286479,0.0002319171,0.000211055,0.0001285431,0.00007820971,0.0002040856,0.0002037074,0.0001873624,0.001239541],"category_scores_gemma":[0.00005716196,0.0001270234,0.0002376949,0.0001222461,0.0001112161,0.0001667815,0.00008797857,0.0002925709,0.0004820918],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000177157,"about_ca_system_score_gemma":0.0001204584,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004138513,"about_ca_topic_score_gemma":0.0006876945,"domain_scores_codex":[0.9999741,0.000006071755,0.000002259736,0.000003023596,0.000009411708,0.000005113993],"domain_scores_gemma":[0.9999803,0.000002898504,0.000006320659,0.000002017024,0.000003687121,0.000004761062],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002684084,0.00005861487,0.0003019971,0.0001532281,0.0000249892,0.0001455843,0.00002224209,0.0003504367,0.9900137,0.0002300257,0.0001114776,0.008319329],"study_design_scores_gemma":[0.0001308227,0.0007475984,0.005299603,0.00001528821,0.00007539574,0.0008043493,0.0000325279,0.001395902,0.9800823,0.00009747327,0.01130594,0.00001271292],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9741569,0.01535325,0.004584035,0.0003503021,0.00003433225,0.00007007051,0.0003649311,0.000130732,0.004955492],"genre_scores_gemma":[0.9789306,0.0101773,0.00598366,0.0001559518,0.00002163734,0.00002993301,0.001342101,0.00002486888,0.003333951],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001239541,"threshold_uncertainty_score":0.004146695,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01252279477656193,"score_gpt":0.260650846427892,"score_spread":0.2481280516513301,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}