{"id":"W2075828741","doi":"10.1021/bi9016457","title":"New Glucosidase Inhibitors from an Ayurvedic Herbal Treatment for Type 2 Diabetes: Structures and Inhibition of Human Intestinal Maltase-Glucoamylase with Compounds from <i>Salacia reticulata</i>","year":2009,"lang":"en","type":"article","venue":"Biochemistry","topic":"Enzyme Production and Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":184,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; University of Waterloo; University of Toronto; Ontario Institute for Cancer Research","funders":"National Center for Research Resources; Canadian Institutes of Health Research","keywords":"Acarbose; Maltase; Alpha-glucosidase; Glycoside hydrolase; Chemistry; Glucosidases; Enzyme; Sucrase; Biochemistry; Type 2 diabetes; Pharmacology; Hydrolysis; Traditional medicine; Diabetes mellitus; Medicine; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003592968,0.0002074868,0.000174966,0.00001934916,0.00007112567,0.00003327549,0.00006158904,0.0001522111,0.00001970465],"category_scores_gemma":[0.00002760921,0.0001843059,0.00004172234,0.00006087367,0.00007515295,0.00001091658,0.00001909062,0.00005106449,3.45096e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002494755,"about_ca_system_score_gemma":0.0000737959,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006294737,"about_ca_topic_score_gemma":0.00001726897,"domain_scores_codex":[0.99907,0.00002146299,0.0002221048,0.0004400321,0.00009969265,0.0001467051],"domain_scores_gemma":[0.999316,0.000008158249,0.0001512095,0.0002856547,0.00009886459,0.0001401003],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000301144,0.0001036087,0.003857449,0.00001853296,0.00003577512,0.00000126152,0.00004129844,0.000002674586,0.993135,0.00000654909,0.0007787989,0.001717857],"study_design_scores_gemma":[0.001368092,0.001348753,0.006485675,0.00005965854,0.00006373606,0.000003538024,0.00005667857,0.00002156071,0.9898667,0.0001778625,0.0003380935,0.0002097074],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986029,0.0005625472,0.0001937119,0.0001373909,0.00005858932,0.0001614424,0.0002335332,0.00002294374,0.00002699989],"genre_scores_gemma":[0.9881677,0.00002903952,0.001672007,0.000135358,0.000723487,0.000007328961,0.009184746,0.0000187035,0.00006163312],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01043514,"threshold_uncertainty_score":0.7515778,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01252279477656193,"score_gpt":0.260650846427892,"score_spread":0.2481280516513301,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}