{"id":"W2075867307","doi":"10.1016/j.bbadis.2006.01.006","title":"Increased guanidino species in murine and human succinate semialdehyde dehydrogenase (SSADH) deficiency","year":2006,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","topic":"Metabolomics and Mass Spectrometry Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Institute of Neurological Disorders and Stroke","keywords":"Arginine; Cerebrospinal fluid; Cerebellum; Enzyme; Pathophysiology; Succinate dehydrogenase; Biochemistry; Chemistry; Metabolite; Endocrinology; Internal medicine; Glycine; Biology; Molecular biology; Amino acid; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001468065,0.0003210145,0.0002063093,0.0006683958,0.0001370805,0.0001641746,0.0001411431,0.0003050481,0.001147716],"category_scores_gemma":[0.0002241741,0.0002118589,0.0001366145,0.0002175108,0.0003341279,0.0001722712,0.0001880242,0.0002456794,0.0001659883],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001201124,"about_ca_system_score_gemma":0.00009402711,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003969858,"about_ca_topic_score_gemma":0.0002697262,"domain_scores_codex":[0.9999293,0.00001515983,0.00001108857,0.00002117729,0.00001263977,0.00001058258],"domain_scores_gemma":[0.9998643,0.00002308153,0.00004266351,0.00001571877,0.000009442822,0.00004471678],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002948606,0.00006837202,0.006068693,0.00005863801,0.0000308828,0.000790471,0.00007769668,0.0001243085,0.9867504,0.00026385,0.00006546985,0.002752479],"study_design_scores_gemma":[0.0003056314,0.002369004,0.1811147,0.0000217522,0.0002277326,0.014107,0.0002341512,0.001993997,0.7956276,0.0007921103,0.003184445,0.00002199035],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980857,0.0008153614,0.0006019375,0.00002378056,0.000006681822,0.000005825211,0.0002004197,0.00001883987,0.0002414581],"genre_scores_gemma":[0.9988519,0.0002903875,0.0003192734,0.00001301879,0.000003310066,0.000008321601,0.0002237792,0.000005464866,0.0002844755],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001147716,"threshold_uncertainty_score":0.003839493,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005573385282606724,"score_gpt":0.2286904878594211,"score_spread":0.2231171025768144,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}