{"id":"W2075872289","doi":"10.1038/nsmb707","title":"A conformational switch in the Piccolo C2A domain regulated by alternative splicing","year":2003,"lang":"en","type":"article","venue":"Nature Structural & Molecular Biology","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":102,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"National Institute of Neurological Disorders and Stroke; Welch Foundation","keywords":"Conformational change; Sequence (biology); Alternative splicing; Chemistry; Biophysics; RNA splicing; Stereochemistry; Binding domain; splice; Binding site; Biochemistry; Biology; RNA; Gene; Gene isoform","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000269386,0.0002233783,0.0001772382,0.00006008768,0.00009253599,0.00002092287,0.0002849572,0.0005748259,0.00004243039],"category_scores_gemma":[0.00005679915,0.0001602876,0.0001097174,0.0001775663,0.0001184516,0.00000609768,0.00002406386,0.0004662973,0.000002678219],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002324847,"about_ca_system_score_gemma":0.00004832379,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003217541,"about_ca_topic_score_gemma":0.00004845942,"domain_scores_codex":[0.9986609,0.0002367017,0.0002714806,0.0003612833,0.0001477009,0.0003219157],"domain_scores_gemma":[0.9994852,0.00001287475,0.000104955,0.0002748449,0.0000769647,0.00004517588],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006475175,0.000009331087,0.001313413,0.000005360969,0.0000423846,0.00001203436,0.0001424053,0.00004033439,0.9729297,0.02511395,0.0001297164,0.000196661],"study_design_scores_gemma":[0.002983515,0.0005063994,0.00901355,0.00001987218,0.00004149402,0.000337003,0.0004278858,0.0002130108,0.8323931,0.02602076,0.1272834,0.0007599926],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876594,0.001588708,0.008597283,0.0004687154,0.0002206442,0.0003353622,0.00003767445,0.000009334367,0.001082884],"genre_scores_gemma":[0.9928762,0.00002710728,0.0005717585,0.001754501,0.00006517157,0.00001854401,0.00462557,0.00001467001,0.00004649898],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1405365,"threshold_uncertainty_score":0.6536339,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002783380474025491,"score_gpt":0.2509093689125754,"score_spread":0.2481259884385499,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}