{"id":"W2075923951","doi":"10.2741/3311","title":"PML nuclear bodies as sites of epigenetic regulation","year":2009,"lang":"en","type":"review","venue":"Frontiers in bioscience","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"Canadian Institutes of Health Research","keywords":"Epigenetics; Promyelocytic leukemia protein; Chromatin; Methyltransferase; Biology; Histone; Nuclear protein; Cell biology; Genetics; Histone methyltransferase; Carcinogenesis; Transcription factor; Cancer research; DNA; Methylation; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004240854,0.0006518289,0.001074021,0.001617394,0.0002609048,0.0009064677,0.001037979,0.00100169,0.001725988],"category_scores_gemma":[0.0003320416,0.0003025921,0.0002536347,0.001265519,0.0008890624,0.0009966342,0.0006087477,0.001298704,0.002354077],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009608411,"about_ca_system_score_gemma":0.0005764499,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009261814,"about_ca_topic_score_gemma":0.00115247,"domain_scores_codex":[0.9998342,0.00003477973,0.00002120337,0.00003497625,0.00005622254,0.0000185157],"domain_scores_gemma":[0.9998677,0.00004577561,0.00003029888,0.000008902522,0.0000316913,0.00001569781],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001443471,0.00004179023,0.000302088,0.007986884,0.0000525612,0.0005959235,0.0001511735,0.0006642512,0.02124276,0.01739811,0.0150815,0.9363386],"study_design_scores_gemma":[0.00001849071,0.00004408592,0.0007318173,0.0006916758,0.00003581402,0.001657515,0.00005261179,0.00008498966,0.005809363,0.003475489,0.9873824,0.00001579337],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000273977,0.9974328,0.0002973686,0.0001636584,0.00009977179,0.000003076536,0.00001060587,0.00001369829,0.001705028],"genre_scores_gemma":[0.003152472,0.9945009,0.0003660116,0.000133011,0.0001336508,0.00000854927,0.00002971712,0.000002452853,0.001673271],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001725988,"threshold_uncertainty_score":0.006971419,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01539398439180146,"score_gpt":0.2833598505311148,"score_spread":0.2679658661393133,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}