{"id":"W2075928340","doi":"10.1016/j.cell.2012.07.035","title":"Dynamic and Coordinated Epigenetic Regulation of Developmental Transitions in the Cardiac Lineage","year":2012,"lang":"en","type":"article","venue":"Cell","topic":"Congenital heart defects research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":633,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network","funders":"National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute","keywords":"Biology; Chromatin; Epigenetics; Histone; ChIA-PET; Enhancer; Lineage (genetic); Bivalent chromatin; Transcription factor; Genetics; Regulation of gene expression; Epigenomics; Gene; Transcriptome; Cellular differentiation; Heart development; Promoter; Gene regulatory network; Epigenesis; Gene expression; DNA methylation; Chromatin remodeling; Embryonic stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001628451,0.00004228056,0.00004958301,0.00002552644,0.00002492267,0.000003935065,0.00004118044,0.00004409381,0.000009980175],"category_scores_gemma":[0.000009364412,0.00003498251,0.00002158943,0.00007547597,0.00004240886,0.000002055729,0.00002097822,0.00003966482,0.000003973078],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007021159,"about_ca_system_score_gemma":0.00002146154,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007779933,"about_ca_topic_score_gemma":0.00002714021,"domain_scores_codex":[0.9996197,0.00006523373,0.0000755742,0.00007239207,0.00005328938,0.0001138292],"domain_scores_gemma":[0.9998541,0.00001152785,0.00001031887,0.00008015573,0.00001867067,0.000025213],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000009934508,0.00003809114,0.004574973,0.00001997254,0.000004595031,2.374445e-7,0.0003156451,0.000003546358,0.9938323,0.000003618441,0.0000452074,0.001151806],"study_design_scores_gemma":[0.000270333,0.00007618729,0.2796931,0.000005739792,0.00000938199,0.000006349353,0.0003418237,0.0002020164,0.7166579,0.000007618659,0.002648164,0.00008140405],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968548,0.001521374,0.0001263282,0.00003158603,0.00002155224,0.0001531078,0.00001041638,0.00000141393,0.001279454],"genre_scores_gemma":[0.9993778,0.00005584979,0.0001993511,0.00001143754,0.00001335957,0.000009892971,0.00006449241,0.000005160667,0.0002625878],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2771745,"threshold_uncertainty_score":0.1426545,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00905742693361101,"score_gpt":0.2543079428132698,"score_spread":0.2452505158796588,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}