{"id":"W2075928340","doi":"10.1016/j.cell.2012.07.035","title":"Dynamic and Coordinated Epigenetic Regulation of Developmental Transitions in the Cardiac Lineage","year":2012,"lang":"en","type":"article","venue":"Cell","topic":"Congenital heart defects research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":633,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network","funders":"National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute","keywords":"Biology; Chromatin; Epigenetics; Histone; ChIA-PET; Enhancer; Lineage (genetic); Bivalent chromatin; Transcription factor; Genetics; Regulation of gene expression; Epigenomics; Gene; Transcriptome; Cellular differentiation; Heart development; Promoter; Gene regulatory network; Epigenesis; Gene expression; DNA methylation; Chromatin remodeling; Embryonic stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000196597,0.0001204085,0.0002087407,0.0003474702,0.0003251887,0.0008596035,0.0004074672,0.0002727544,0.001973872],"category_scores_gemma":[0.0003967524,0.0002231694,0.0001579528,0.0002270836,0.0004142531,0.0006678709,0.0006011153,0.0004172836,0.0004351324],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004144016,"about_ca_system_score_gemma":0.0003263878,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007733175,"about_ca_topic_score_gemma":0.002677284,"domain_scores_codex":[0.9997913,0.00002475107,0.000009647279,0.00007109242,0.00005527182,0.00004783692],"domain_scores_gemma":[0.9997653,0.00004425444,0.00005003889,0.00003923861,0.00005894549,0.00004213046],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008071278,0.00001246056,0.003303557,0.00002941591,0.0000122961,0.0001133655,0.0001359423,0.0002555448,0.9792979,0.00424711,0.0001914996,0.01232028],"study_design_scores_gemma":[0.00005512935,0.0002923713,0.2842425,0.00006849172,0.00007599613,0.0009372414,0.0009224935,0.006275252,0.6725441,0.007162414,0.02736652,0.00005741611],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9492929,0.008903377,0.02553008,0.0006619088,0.0001446433,0.0000301658,0.0005053278,0.0001960175,0.01473556],"genre_scores_gemma":[0.991435,0.001479014,0.002411575,0.0001012203,0.00003832849,0.00001846473,0.0002216935,0.0000472444,0.004247624],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001973872,"threshold_uncertainty_score":0.006603241,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00905742693361101,"score_gpt":0.2543079428132698,"score_spread":0.2452505158796588,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}