{"id":"W2075929424","doi":"10.1165/rcmb.4866","title":"Polyethylene Glycol Conjugation at Cys <b>232</b> Prolongs the Half-Life of <b>α</b> 1 Proteinase Inhibitor","year":2002,"lang":"en","type":"article","venue":"American Journal of Respiratory Cell and Molecular Biology","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Université de Sherbrooke","funders":"","keywords":"In vivo; PEGylation; Elastase; Chemistry; PEG ratio; Polyethylene glycol; Pharmacology; Ex vivo; Neutrophil elastase; Pancreatic elastase; Pharmacokinetics; Serine; Biochemistry; Enzyme; In vitro; Immunology; Medicine; Biology; Inflammation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009044902,0.0002813248,0.0001131358,0.00007342437,0.00006895659,0.0001534523,0.00009379257,0.0001857163,0.0005808704],"category_scores_gemma":[0.0001414836,0.00008217087,0.0001038835,0.00007522015,0.0001367019,0.0001685679,0.00006986151,0.0002824353,0.0002053859],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001914994,"about_ca_system_score_gemma":0.0001070829,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002514194,"about_ca_topic_score_gemma":0.000204702,"domain_scores_codex":[0.9999583,0.000008566494,0.000003113828,0.000009974051,0.00001027374,0.000009835697],"domain_scores_gemma":[0.9999448,0.000008924409,0.00002597693,0.000005009555,0.000004551062,0.00001068167],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001512887,0.00001672309,0.0001437826,0.00001196031,0.000002832008,0.00002272729,0.000004539861,0.00007509457,0.997398,0.00005783963,0.00001612601,0.002099077],"study_design_scores_gemma":[0.00000992728,0.0003372252,0.001378436,0.000001346235,0.000007035301,0.0001553128,0.000002566926,0.0003096086,0.9967681,0.00002348921,0.001005339,0.000001631393],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958974,0.000862512,0.002343541,0.00005852736,0.000007850336,0.00001197721,0.00005626589,0.00003798226,0.0007239867],"genre_scores_gemma":[0.9955811,0.0005768273,0.002386113,0.00003647375,0.000007084515,0.000009548015,0.0001454491,0.00001163944,0.001245728],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005808704,"threshold_uncertainty_score":0.001943231,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01082274599607707,"score_gpt":0.2527288331014643,"score_spread":0.2419060871053872,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}