{"id":"W2075930146","doi":"10.1002/pro.193","title":"Determination and application of empirically derived detergent phase boundaries to effectively crystallize membrane proteins","year":2009,"lang":"en","type":"article","venue":"Protein Science","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Division of Materials Research; National Center for Research Resources; National Institute of General Medical Sciences; National Science Foundation; National Institutes of Health; School of Medicine, New York University; York University","keywords":"Crystallization; Protein crystallization; Membrane; Membrane protein; Phase (matter); Lipid bilayer; Chemistry; Phase boundary; Structural biology; Solubility; Structural genomics; Chemical engineering; Materials science; Protein structure; Biochemistry; Organic chemistry; Engineering","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002299691,0.0006392737,0.0007307481,0.001233779,0.0007942258,0.001077292,0.0006353229,0.0006322149,0.0008416136],"category_scores_gemma":[0.006952728,0.000525508,0.0004199584,0.001205523,0.0007480746,0.001342275,0.001053017,0.001631993,0.0005818403],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001152727,"about_ca_system_score_gemma":0.001367857,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00197251,"about_ca_topic_score_gemma":0.003228569,"domain_scores_codex":[0.9985384,0.0003684759,0.0002140923,0.0002106228,0.0005603345,0.0001080612],"domain_scores_gemma":[0.9974837,0.001275592,0.0003712245,0.0003272735,0.000458557,0.00008364632],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002326441,0.0002902349,0.004224285,0.0002749333,0.0000274092,0.00009403731,0.0001932989,0.01331377,0.9491219,0.003768597,0.0004328894,0.02802606],"study_design_scores_gemma":[0.0000278596,0.000165515,0.001674631,0.00004131507,0.00001630729,0.00007296776,0.00006687844,0.03774059,0.9552527,0.001387734,0.003523897,0.00002966547],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6572027,0.003798601,0.3256137,0.0005486979,0.00007049268,0.0008383436,0.001918535,0.001688214,0.008320724],"genre_scores_gemma":[0.6987029,0.003306353,0.2932037,0.0001536329,0.00001635307,0.0008352944,0.002343843,0.000484215,0.0009537042],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002299691,"threshold_uncertainty_score":0.01216209,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006230215105346971,"score_gpt":0.2888235307838544,"score_spread":0.2825933156785074,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}