{"id":"W2075947961","doi":"10.1186/1471-2407-13-300","title":"Gonadotropin-releasing hormone type II (GnRH-II) agonist regulates the invasiveness of endometrial cancer cells through the GnRH-I receptor and mitogen-activated protein kinase (MAPK)-dependent activation of matrix metalloproteinase (MMP)-2","year":2013,"lang":"en","type":"article","venue":"BMC Cancer","topic":"Hypothalamic control of reproductive hormones","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Chang Gung Medical Foundation","keywords":"Agonist; Endocrinology; Internal medicine; Gonadotropin-releasing hormone; Motility; MAPK/ERK pathway; Gonadotropin-releasing hormone receptor; Receptor; Cancer research; Biology; Chemistry; Kinase; Medicine; Hormone; Luteinizing hormone; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009301493,0.0002039115,0.0001783857,0.000117029,0.00008768116,0.0001684681,0.00008989836,0.000112054,0.0008572066],"category_scores_gemma":[0.00009572221,0.00008944234,0.0002937078,0.0001144447,0.0001298782,0.00007065685,0.00008233613,0.0002549308,0.0001546633],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001136062,"about_ca_system_score_gemma":0.0001597694,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003179138,"about_ca_topic_score_gemma":0.0006130268,"domain_scores_codex":[0.9999441,0.0000106683,0.000006642193,0.000007961668,0.00001604099,0.00001455996],"domain_scores_gemma":[0.9999566,0.000005799356,0.00001575887,0.000003136081,0.000005309217,0.00001333744],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004661915,0.00007458914,0.003067117,0.0002306357,0.00002613421,0.0002846499,0.00002995756,0.00005807602,0.9911811,0.00005224457,0.0002588464,0.004270491],"study_design_scores_gemma":[0.0002956352,0.003173825,0.1602481,0.00007255816,0.0001800584,0.003305254,0.0003688545,0.001905022,0.8168258,0.0001348226,0.01346923,0.00002087791],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871566,0.009197274,0.0009913277,0.00021144,0.00008557625,0.00004291962,0.0003328404,0.00003849829,0.001943631],"genre_scores_gemma":[0.9912306,0.005802516,0.001061235,0.0001356495,0.00002635547,0.00004274012,0.0003858703,0.000008006779,0.001306997],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008572066,"threshold_uncertainty_score":0.002867639,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02736667845981541,"score_gpt":0.2795801464592204,"score_spread":0.252213467999405,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}