{"id":"W2075962869","doi":"10.1007/s12640-009-9074-5","title":"4-Hydroxy-2-Nonenal Induces Mitochondrial Dysfunction and Aberrant Axonal Outgrowth in Adult Sensory Neurons that Mimics Features of Diabetic Neuropathy","year":2009,"lang":"en","type":"article","venue":"Neurotoxicity Research","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":73,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba; St. Boniface Hospital","funders":"Canadian Institutes of Health Research; Hospital Research Foundation","keywords":"Axon; Mitochondrion; Sensory neuron; Dorsal root ganglion; Biology; Neurodegeneration; Axoplasmic transport; Sensory system; Neurotoxicity; Cell biology; Neuroscience; Pathology; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002236331,0.0003110013,0.0002657707,0.0003909518,0.0002323401,0.0003146563,0.0003714741,0.0004778472,0.0009116759],"category_scores_gemma":[0.0001961099,0.0002165544,0.000331441,0.0002600949,0.0002950778,0.0004207033,0.0002200291,0.0007656841,0.0002295592],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004218575,"about_ca_system_score_gemma":0.0004398297,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00245481,"about_ca_topic_score_gemma":0.004889211,"domain_scores_codex":[0.9997823,0.0000366058,0.00003079538,0.00003553299,0.00005581782,0.00005903903],"domain_scores_gemma":[0.9997903,0.00004058879,0.00004940284,0.00004132646,0.0000219919,0.00005632703],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006964775,0.0001381608,0.000688209,0.00003431687,0.00001345413,0.0006446744,0.00003113563,0.0001275742,0.9966587,0.0001204391,0.00002512873,0.0008218098],"study_design_scores_gemma":[0.00005271269,0.00181952,0.01229183,0.000009179489,0.00003998271,0.001860166,0.0001379382,0.0007623007,0.9821093,0.0001278316,0.0007802171,0.000008974117],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971764,0.0006256279,0.0008003826,0.00004745704,0.00003210014,0.00002597152,0.0002172078,0.00003192192,0.001042945],"genre_scores_gemma":[0.9971595,0.0005113581,0.0006500609,0.00002929963,0.000005522796,0.00001789046,0.0002901712,0.000007647319,0.001328643],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00245481,"threshold_uncertainty_score":0.004881084,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05304819937981196,"score_gpt":0.3208477965360264,"score_spread":0.2677995971562144,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}