{"id":"W2075985899","doi":"10.1158/1538-7445.am2013-4591","title":"Abstract 4591: Whole genome sequencing of SHH medulloblastomas predicts molecular groups of responders and non-responders to SMO-inhibition .","year":2013,"lang":"en","type":"article","venue":"Cancer Research","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"PTCH1; Sonic hedgehog; GLI2; Transcriptome; Biology; Germline mutation; Genetics; Gene; Germline; Whole genome sequencing; Medicine; Cancer research; Genome; Oncology; Mutation; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001669562,0.0001717023,0.000206909,0.00060671,0.0001529517,0.0002156309,0.0001291322,0.0002314182,0.001779243],"category_scores_gemma":[0.0005280584,0.0001223935,0.0002586924,0.0003225518,0.0001042802,0.00009407939,0.0001730148,0.0002056402,0.0003333636],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00017815,"about_ca_system_score_gemma":0.0001240485,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002072278,"about_ca_topic_score_gemma":0.002768645,"domain_scores_codex":[0.9998614,0.0000201962,0.00001120666,0.00004389006,0.00003463042,0.00002864825],"domain_scores_gemma":[0.999773,0.00007789016,0.00006117103,0.00001755435,0.00002056957,0.00004985274],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001351764,0.00007158717,0.6680453,0.00007895614,0.0002500232,0.00123933,0.0003196242,0.000347253,0.3030438,0.0001347911,0.001207218,0.02391038],"study_design_scores_gemma":[0.00001325301,0.0001598485,0.9861609,0.000005534896,0.00006636612,0.001407022,0.00007976566,0.0006410712,0.009763811,0.00005752142,0.0016415,0.000003481845],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963391,0.0003904762,0.0007843227,0.00003640887,0.000006134845,0.00001267441,0.001915956,0.00004015849,0.0004747939],"genre_scores_gemma":[0.9941071,0.0001637755,0.001223933,0.00005001144,0.000007734315,0.00001799933,0.003706737,0.00002988621,0.0006927709],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002072278,"threshold_uncertainty_score":0.00595212,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04279592682923148,"score_gpt":0.3357785422620193,"score_spread":0.2929826154327878,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}