{"id":"W2076026454","doi":"10.1074/jbc.275.19.14295","title":"Identification and Characterization of CKIP-1, a Novel Pleckstrin Homology Domain-containing Protein That Interacts with Protein Kinase CK2","year":2000,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":113,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Western University","funders":"National Cancer Institute; Terry Fox Foundation; Cancer Research Society","keywords":"Pleckstrin homology domain; Biology; Cell biology; Vesicle-associated membrane protein 8; Autophagy-related protein 13; Protein–protein interaction; Casein kinase 2; Retinoblastoma-like protein 1; Biochemistry; Fusion protein; Protein kinase domain; SH3 domain; Immunoprecipitation; HSPA9; Protein kinase A; Molecular biology; Kinase; Peptide sequence; Mitogen-activated protein kinase kinase; Membrane protein; Gene; Proto-oncogene tyrosine-protein kinase Src; Membrane","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003138576,0.0001564653,0.0002486087,0.00003250247,0.00004986047,0.00002619685,0.0001406531,0.000217711,0.0001013764],"category_scores_gemma":[0.00007095883,0.0001146939,0.0000749339,0.00008232213,0.0001540087,0.00001625096,0.00003690278,0.0001625404,6.468995e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000181845,"about_ca_system_score_gemma":0.00006702829,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001586037,"about_ca_topic_score_gemma":4.623214e-7,"domain_scores_codex":[0.998973,0.00005447366,0.0004488115,0.0002256928,0.0001367332,0.0001612769],"domain_scores_gemma":[0.9990173,0.000009433871,0.0005607514,0.0001507586,0.0001660039,0.00009572908],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009685791,0.0001151543,0.0004959484,0.0000516101,0.00003990021,0.00001501834,0.00003214122,0.000007211613,0.9955433,0.00002217452,0.000001956145,0.002707026],"study_design_scores_gemma":[0.0009900683,0.0005067757,0.003263376,0.0001664151,0.00001207318,0.0002717933,0.00006602515,0.00001504151,0.9935356,0.00007846033,0.000953141,0.0001412815],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961094,0.0001910759,0.003161092,0.0001480132,0.00001070306,0.0002370124,0.00001626003,0.000005601331,0.0001208134],"genre_scores_gemma":[0.9983765,0.00003900815,0.001117357,0.00003781584,0.0001325512,0.00001849075,0.00007252772,0.00001045051,0.0001952814],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002767428,"threshold_uncertainty_score":0.4677083,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01432860042294042,"score_gpt":0.2317003697967105,"score_spread":0.2173717693737701,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}