{"id":"W2076027168","doi":"10.1182/blood-2010-12-322727","title":"Increased HIV-specific CD8+ T-cell cytotoxic potential in HIV elite controllers is associated with T-bet expression","year":2011,"lang":"en","type":"article","venue":"Blood","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":172,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Center for Research Resources; National Institute of Allergy and Infectious Diseases; Center for AIDS Research, University of Washington; amfAR, The Foundation for AIDS Research","keywords":"Granulysin; Perforin; Granzyme; Granzyme B; Cytotoxic T cell; Granzyme A; Biology; CD8; Effector; T cell; Immunology; Cell biology; Immune system; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0001831969,0.0002200951,0.0003407318,0.0001635105,0.0001346572,0.0000152335,0.0001992511,0.0002408542,0.001899318],"category_scores_gemma":[0.00002461241,0.0001632378,0.00008856728,0.0001516133,0.0001373121,0.00007701883,0.00005859402,0.0003035729,0.001832914],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004606147,"about_ca_system_score_gemma":0.00008175122,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001391955,"about_ca_topic_score_gemma":0.0000443582,"domain_scores_codex":[0.9983724,0.0003434078,0.0002476202,0.0003768399,0.0000788137,0.0005808808],"domain_scores_gemma":[0.9993804,0.00007780569,0.000102193,0.0003122817,0.00005655847,0.00007077096],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001729562,0.004092989,0.05122546,0.000008140086,0.0004212244,0.0005167074,0.0008901816,7.991534e-7,0.9356297,0.00001620539,0.005268423,0.0002005517],"study_design_scores_gemma":[0.05971669,0.0008346377,0.0922558,0.0001638991,0.0001407537,0.00004328221,0.0003267784,0.000002973793,0.8425758,0.00004653506,0.00348574,0.0004070374],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908547,0.001732852,0.00003328903,0.00004919862,0.00005328958,0.0004848935,0.0003167751,0.00006578195,0.006409227],"genre_scores_gemma":[0.9965696,0.0001650917,0.000107413,0.00005998035,0.00001488383,0.00008434737,0.0005365419,0.00002347143,0.002438665],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09305388,"threshold_uncertainty_score":0.9990131,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01220288022716359,"score_gpt":0.2033409613603794,"score_spread":0.1911380811332158,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}