{"id":"W2076027649","doi":"10.1016/s0736-0266(02)00099-2","title":"Effect of pamidronate on the stimulation of macrophage TNF‐α release by ultra‐high‐molecular‐weight polyethylene particles: a role for apoptosis","year":2002,"lang":"en","type":"article","venue":"Journal of Orthopaedic Research®","topic":"Orthopaedic implants and arthroplasty","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Jewish General Hospital","keywords":"Stimulation; Apoptosis; Macrophage; Tumor necrosis factor alpha; Ultra-high-molecular-weight polyethylene; Polyethylene; Chemistry; Cancer research; Cell biology; Internal medicine; Endocrinology; Materials science; Medicine; Biology; In vitro; Biochemistry; Composite material","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003891831,0.00021118,0.000619321,0.0003467122,0.0001547337,0.00002114184,0.0002174388,0.0001263661,0.0004689186],"category_scores_gemma":[0.002324089,0.0001201783,0.0004567518,0.0004620304,0.0003838808,0.0001249052,0.00003637399,0.0006745363,0.00001216721],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006124335,"about_ca_system_score_gemma":0.00009596815,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002387889,"about_ca_topic_score_gemma":7.992709e-7,"domain_scores_codex":[0.9959336,0.0007201852,0.0009325377,0.0002231067,0.001677693,0.0005128976],"domain_scores_gemma":[0.9959694,0.002146944,0.0005791358,0.0003895084,0.0005828444,0.0003321601],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007760956,0.001359434,0.01579803,0.0008063353,0.0005916992,0.0002076035,0.0005159982,0.0001695731,0.6283571,0.00046844,0.01636461,0.3276002],"study_design_scores_gemma":[0.01028504,0.01860153,0.004458739,0.0009582442,0.0003141108,0.0001460727,0.0001749622,0.002478759,0.9562136,0.0001763621,0.006010034,0.0001825613],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993963,0.002219254,0.0003216235,0.002016608,0.000150019,0.0008083315,0.00007836505,0.000008887278,0.0004339094],"genre_scores_gemma":[0.9981058,0.0009123396,0.0001574357,0.0001208302,0.0002203019,0.00002070783,0.000008343048,0.00004044183,0.0004137912],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3278565,"threshold_uncertainty_score":0.5134329,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02300302136910132,"score_gpt":0.313714066993028,"score_spread":0.2907110456239267,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}