{"id":"W2076038066","doi":"10.1007/s11095-007-9428-8","title":"Influence of Plasma Cholesterol and Triglyceride Concentrations and Eritoran (E5564) Micelle Size on its Plasma Pharmacokinetics and Ex Vivo Activity Following Single Intravenous Bolus Dose Into Healthy Female Rabbits","year":2007,"lang":"en","type":"article","venue":"Pharmaceutical Research","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"University of British Columbia; Eisai","keywords":"Pharmacokinetics; Triglyceride; Ex vivo; Internal medicine; Pharmacodynamics; Endocrinology; Cholesterol; Pharmacology; In vivo; Bolus (digestion); Chemistry; Blood plasma; Medicine; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004745787,0.0004919966,0.0005532011,0.0002806024,0.0001343152,0.0004067045,0.0003075181,0.0004350065,0.001056462],"category_scores_gemma":[0.0005975492,0.0002924125,0.0003696992,0.0001905101,0.0005517653,0.0006863804,0.0001639885,0.0008338446,0.000417708],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002781444,"about_ca_system_score_gemma":0.0002862296,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006467877,"about_ca_topic_score_gemma":0.0006185321,"domain_scores_codex":[0.9996994,0.00006129062,0.00002812497,0.00007706283,0.00004261735,0.00009157305],"domain_scores_gemma":[0.9996406,0.0001237433,0.00009943027,0.00004603705,0.0000249135,0.00006531706],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.02976612,0.0009830948,0.0005995627,0.00006964168,0.00004429533,0.0001255988,0.0001076816,0.0003869841,0.9581608,0.0001786391,0.0001069006,0.009470528],"study_design_scores_gemma":[0.0004224142,0.01243373,0.003082925,0.000005878146,0.0001041277,0.0001166897,0.00003787466,0.001150162,0.9817199,0.00008370597,0.000824745,0.000017866],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975554,0.0006834866,0.0009896926,0.00005876776,0.00003337092,0.00003032508,0.0001609769,0.00004983262,0.00043807],"genre_scores_gemma":[0.9944534,0.0008089085,0.001098095,0.00006648631,0.00004902389,0.00007288284,0.0002578456,0.00003728516,0.003156021],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001056462,"threshold_uncertainty_score":0.003534198,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07804843932173165,"score_gpt":0.4022562446270074,"score_spread":0.3242078053052757,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}