{"id":"W2076038066","doi":"10.1007/s11095-007-9428-8","title":"Influence of Plasma Cholesterol and Triglyceride Concentrations and Eritoran (E5564) Micelle Size on its Plasma Pharmacokinetics and Ex Vivo Activity Following Single Intravenous Bolus Dose Into Healthy Female Rabbits","year":2007,"lang":"en","type":"article","venue":"Pharmaceutical Research","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"University of British Columbia; Eisai","keywords":"Pharmacokinetics; Triglyceride; Ex vivo; Internal medicine; Pharmacodynamics; Endocrinology; Cholesterol; Pharmacology; In vivo; Bolus (digestion); Chemistry; Blood plasma; Medicine; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001805437,0.0002101328,0.000342807,0.0002065128,0.0004614913,0.00005381415,0.0001490393,0.0002305807,0.00004768848],"category_scores_gemma":[0.000953817,0.0002047027,0.00004160481,0.0002667161,0.000612557,0.0002468955,0.0001826082,0.0008541841,0.00002514273],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009824407,"about_ca_system_score_gemma":0.0001276064,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008553852,"about_ca_topic_score_gemma":0.00002605555,"domain_scores_codex":[0.9975927,0.0006544723,0.0004276359,0.0004125444,0.0001959494,0.00071669],"domain_scores_gemma":[0.9962645,0.003129395,0.00009131732,0.0001701431,0.0001656323,0.0001789694],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006985739,0.0003053262,0.0008028828,0.0001690991,0.00009112892,0.00002105712,0.00136346,0.00001968348,0.9567971,0.00009481418,0.0000389916,0.03331072],"study_design_scores_gemma":[0.005218594,0.0009059258,0.01121684,0.00009322706,0.00004117404,0.00004955031,0.0002202494,0.0004479527,0.9733672,0.00002028082,0.008242898,0.0001760743],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995979,0.001972629,0.00002140512,0.0008245075,0.0001633832,0.0007258274,0.00001163784,0.00002880005,0.0002728392],"genre_scores_gemma":[0.9982993,0.00122154,0.00005572632,0.0001454397,0.00004458932,0.0000180306,0.000005662861,0.00002048368,0.0001892128],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03313464,"threshold_uncertainty_score":0.8347532,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07804843932173165,"score_gpt":0.4022562446270074,"score_spread":0.3242078053052757,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}