{"id":"W2076043109","doi":"10.1182/blood-2012-07-440776","title":"IgM+IgD+CD27+ B cells are markedly reduced in IRAK-4–, MyD88-, and TIRAP- but not UNC-93B–deficient patients","year":2012,"lang":"en","type":"article","venue":"Blood","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":102,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; Hospital for Sick Children; University of Toronto","funders":"National Center for Advancing Translational Sciences; National Institute of Allergy and Infectious Diseases; North Carolina State University","keywords":"TRIF; Immunoglobulin D; Somatic hypermutation; TLR3; B cell; Biology; Signal transducing adaptor protein; TLR9; Immunology; Molecular biology; Cell biology; Antibody; Toll-like receptor; Signal transduction; Immune system; Innate immune system; Gene; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002249662,0.0001966365,0.000237336,0.0001680091,0.0001281629,0.00002025272,0.0001039374,0.0002454224,0.0007632765],"category_scores_gemma":[0.00005690141,0.0001817268,0.00006719083,0.0001271688,0.00007427934,0.0001927958,0.00006690789,0.0003320578,0.001000493],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004137525,"about_ca_system_score_gemma":0.00001622012,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009036154,"about_ca_topic_score_gemma":0.00001040303,"domain_scores_codex":[0.9987175,0.0001755152,0.0003336919,0.0002722369,0.00004852158,0.0004525271],"domain_scores_gemma":[0.9994203,0.0000684444,0.0001612894,0.0002448857,0.00006770586,0.00003735269],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003969735,0.002304739,0.06237516,0.00003552159,0.0001277889,0.000002436931,0.0009707769,0.000001271336,0.9188942,0.00008700048,0.01326234,0.00154181],"study_design_scores_gemma":[0.004508885,0.0002497894,0.2897007,0.00006019075,0.00009048321,0.00003111504,0.0006172434,0.00000213062,0.6383224,0.000005612726,0.06609974,0.0003117608],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990501,0.001328579,0.000006224537,0.00007719341,0.004206339,0.0002486176,0.00001341855,0.00004969322,0.003568925],"genre_scores_gemma":[0.9884175,0.0001029525,0.00002270653,0.0003866924,0.00005263741,0.00002240016,0.00009998185,0.0000203144,0.01087483],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2805718,"threshold_uncertainty_score":0.9997773,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009829338867714763,"score_gpt":0.2024181132621475,"score_spread":0.1925887743944327,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}