{"id":"W2076043109","doi":"10.1182/blood-2012-07-440776","title":"IgM+IgD+CD27+ B cells are markedly reduced in IRAK-4–, MyD88-, and TIRAP- but not UNC-93B–deficient patients","year":2012,"lang":"en","type":"article","venue":"Blood","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":102,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; Hospital for Sick Children; University of Toronto","funders":"National Center for Advancing Translational Sciences; National Institute of Allergy and Infectious Diseases; North Carolina State University","keywords":"TRIF; Immunoglobulin D; Somatic hypermutation; TLR3; B cell; Biology; Signal transducing adaptor protein; TLR9; Immunology; Molecular biology; Cell biology; Antibody; Toll-like receptor; Signal transduction; Immune system; Innate immune system; Gene; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000308764,0.001679171,0.0008330334,0.001822656,0.0007741289,0.0007008039,0.0005759685,0.00120776,0.003358707],"category_scores_gemma":[0.000776694,0.0007103471,0.0004363275,0.0007628004,0.0006834467,0.0005858531,0.0005210018,0.0007855877,0.0007838506],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003400265,"about_ca_system_score_gemma":0.0001879172,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008791135,"about_ca_topic_score_gemma":0.0005179822,"domain_scores_codex":[0.9995709,0.00007173621,0.00006239324,0.0001359517,0.00008538993,0.00007347654],"domain_scores_gemma":[0.9994703,0.00009238458,0.0001732798,0.00003698219,0.00004521958,0.000181807],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01291488,0.001073516,0.3752103,0.0004328513,0.0007233211,0.04766497,0.001599813,0.0008194521,0.5238313,0.0008058253,0.001448161,0.03347568],"study_design_scores_gemma":[0.0005819523,0.00470767,0.8168697,0.00008006078,0.0008235209,0.1296826,0.0006183786,0.001314038,0.03947279,0.0005832691,0.005189965,0.00007613001],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979275,0.0004785919,0.0002726029,0.00005072726,0.000008397858,0.00001807896,0.0002415646,0.00006219117,0.0009402792],"genre_scores_gemma":[0.998738,0.0002319105,0.0002487467,0.00005114551,0.00001958886,0.00001615668,0.0002059111,0.00001787741,0.0004706305],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003358707,"threshold_uncertainty_score":0.01123607,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009829338867714763,"score_gpt":0.2024181132621475,"score_spread":0.1925887743944327,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}