{"id":"W2076045728","doi":"10.1021/jo062064j","title":"Aryl Amidation Routes to Dihydropyrrolo[3,2-<i>e</i>]indoles and Pyrrolo[3,2-<i>f</i>]tetrahydroquinolines:  Total Synthesis of the (±)-CC-1065 CPI Subunit","year":2006,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Synthesis and Biological Activity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Trifluoromethanesulfonate; Chemistry; Aryl; Intramolecular force; Yield (engineering); Stereochemistry; Protein subunit; Total synthesis; Combinatorial chemistry; Organic chemistry; Alkyl; Catalysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001781551,0.0004950787,0.0002683377,0.0002131681,0.0001591407,0.0001886366,0.0004087301,0.0002160353,0.001295234],"category_scores_gemma":[0.00018257,0.0001440012,0.000259448,0.0002808652,0.0001797099,0.0002963917,0.0003262986,0.0005182612,0.0008136453],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003186311,"about_ca_system_score_gemma":0.0004280095,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005458575,"about_ca_topic_score_gemma":0.0007158561,"domain_scores_codex":[0.999854,0.00001354162,0.00001529581,0.00003425329,0.00004123728,0.00004166039],"domain_scores_gemma":[0.9999106,0.00001061242,0.00002696371,0.00001371402,0.00001774526,0.00002036057],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000619198,0.00003041076,0.0001200209,0.0001248291,0.00001010028,0.0001369772,0.00009106378,0.0003110755,0.9848129,0.001535897,0.0002370351,0.01252775],"study_design_scores_gemma":[0.00002066097,0.0003984384,0.0008417395,0.000009021401,0.00001682805,0.0003209629,0.00002463816,0.0004692227,0.9876266,0.0002251611,0.01003413,0.00001259481],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.828386,0.004136441,0.1375664,0.0002376052,0.0001855301,0.0005129376,0.001714216,0.0009763177,0.02628456],"genre_scores_gemma":[0.9539566,0.002149828,0.03591145,0.00007165534,0.00002034514,0.000188226,0.001039757,0.00009813486,0.006563948],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001295234,"threshold_uncertainty_score":0.004333019,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004175871051699309,"score_gpt":0.1886185955287834,"score_spread":0.184442724477084,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}