{"id":"W2076045728","doi":"10.1021/jo062064j","title":"Aryl Amidation Routes to Dihydropyrrolo[3,2-<i>e</i>]indoles and Pyrrolo[3,2-<i>f</i>]tetrahydroquinolines:  Total Synthesis of the (±)-CC-1065 CPI Subunit","year":2006,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Synthesis and Biological Activity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Trifluoromethanesulfonate; Chemistry; Aryl; Intramolecular force; Yield (engineering); Stereochemistry; Protein subunit; Total synthesis; Combinatorial chemistry; Organic chemistry; Alkyl; Catalysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005512335,0.0002119577,0.0003087315,0.00001836502,0.0001207306,0.00002380489,0.0005035537,0.0001814818,0.00005133696],"category_scores_gemma":[0.0005477493,0.0001134823,0.0001665791,0.0001720885,0.0002250469,0.000009948519,0.0002270257,0.0002087423,0.000001943774],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002345384,"about_ca_system_score_gemma":0.0000686218,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002301325,"about_ca_topic_score_gemma":0.00001428084,"domain_scores_codex":[0.9987529,0.00009893082,0.0004818645,0.0001893272,0.0002499033,0.000227101],"domain_scores_gemma":[0.9987435,0.0001751128,0.0004762644,0.0003785647,0.0001476854,0.00007886316],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001833246,0.0002742431,0.004586907,0.00002860935,0.00005676761,0.00000128365,0.00002043167,0.00002881382,0.9934422,0.000002241662,0.0003683152,0.001006891],"study_design_scores_gemma":[0.0004403445,0.0001066192,0.02260907,0.00005442472,0.00009971092,0.0002609332,0.0001011415,0.00001216232,0.9754474,0.000089899,0.0006323617,0.0001459877],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974677,0.0007787181,0.0001255322,0.001181904,0.00007252182,0.0001010373,0.00002054048,0.000005939574,0.0002461308],"genre_scores_gemma":[0.9989143,0.0002502484,0.00008217106,0.0001399944,0.0004444069,0.000002299963,0.000004027483,0.00001854759,0.000144025],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01802216,"threshold_uncertainty_score":0.4627674,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004175871051699309,"score_gpt":0.1886185955287834,"score_spread":0.184442724477084,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}