{"id":"W2076047956","doi":"10.1038/ni0509-455","title":"Crohn's disease-associated Nod2 mutants reduce IL10 transcription","year":2009,"lang":"en","type":"letter","venue":"Nature Immunology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"NOD2; Pathogenesis; Crohn's disease; Cytokine; ATG16L1; Transcription factor; Interleukin 10; Mutant; Immunology; Disease; Biology; Transcription (linguistics); Gene; Medicine; Genetics; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.0001572181,0.0006662147,0.0004684993,0.0001904909,0.000169703,0.00005122691,0.0007839555,0.006532516,0.0001339157],"category_scores_gemma":[0.0003494528,0.00070494,0.0004564526,0.0001432273,0.0002462185,0.000008528727,0.00009090167,0.003840486,0.0001130358],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001405828,"about_ca_system_score_gemma":0.0004405484,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004626483,"about_ca_topic_score_gemma":0.00001621779,"domain_scores_codex":[0.9968925,0.0004290787,0.0004571356,0.001033104,0.0003325915,0.0008556587],"domain_scores_gemma":[0.9981287,0.00001829145,0.0003277524,0.001111312,0.0003009714,0.0001130041],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001006472,0.0001240503,0.0001483865,0.00006637889,0.0005561625,0.01068759,0.00002063277,0.000003418254,0.07941188,0.00002999236,0.9064733,0.001471763],"study_design_scores_gemma":[0.001204023,0.0001303746,0.193851,0.00008663045,0.0002675357,0.00005392257,0.00000576807,0.000003710251,0.002016778,0.0003245525,0.8012234,0.0008322423],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"commentary","genre_scores_codex":[0.6472837,0.03372497,0.00003600613,0.3041502,0.00715626,0.001870381,0.001973329,0.000375866,0.003429323],"genre_scores_gemma":[0.3839377,0.0008824999,0.00007291284,0.5842685,0.005131205,0.0001120057,0.01666053,0.0002344388,0.008700198],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.2801183,"threshold_uncertainty_score":0.9995402,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005271039715555079,"score_gpt":0.2320371294539867,"score_spread":0.2267660897384317,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}