{"id":"W2076095845","doi":"10.1186/1471-213x-10-15","title":"BMP-2 functions independently of SHH signaling and triggers cell condensation and apoptosis in regenerating axolotl limbs","year":2010,"lang":"en","type":"article","venue":"BMC Developmental Biology","topic":"Developmental Biology and Gene Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Institut de Recherche Clinique De Montréal; Université de Montréal; Réseau de Recherche en Santé Buccodentaire et Osseuse","keywords":"Axolotl; Cyclopamine; Sonic hedgehog; Biology; Noggin; Hedgehog; Cell biology; Bone morphogenetic protein; Regeneration (biology); Blastema; Hedgehog signaling pathway; Limb development; Apical ectodermal ridge; Zone of polarizing activity; Limb bud; Anatomy; Signal transduction; Ectoderm; Genetics; Embryogenesis; Embryo","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007639528,0.0003618109,0.000151822,0.000302657,0.0001581333,0.0002228067,0.0001829424,0.0002630183,0.001314688],"category_scores_gemma":[0.00006308273,0.0001692414,0.000235346,0.0001140175,0.0002200625,0.0001295027,0.0001751956,0.000414517,0.0004651093],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003212552,"about_ca_system_score_gemma":0.0001983876,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006206796,"about_ca_topic_score_gemma":0.001137792,"domain_scores_codex":[0.9999102,0.000007795581,0.000007928272,0.0000158761,0.00003090117,0.00002722171],"domain_scores_gemma":[0.9999095,0.00001975521,0.00002494108,0.000009503175,0.000009816158,0.00002657609],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006581507,0.000008205974,0.0002456553,0.00002472697,0.000002824394,0.00007449593,0.000007591051,0.00001590891,0.9991816,0.00003456782,0.00002117912,0.000317294],"study_design_scores_gemma":[0.00002673329,0.0001861586,0.01436477,0.000006953481,0.00001297144,0.0004729646,0.00002586996,0.000458839,0.9829798,0.00003024874,0.001432003,0.000002666138],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942119,0.001428181,0.001447988,0.00005057502,0.00003130121,0.00003172925,0.0004977837,0.00009988609,0.002200778],"genre_scores_gemma":[0.9892948,0.0007287679,0.001457145,0.00007390956,0.00001629532,0.00006693181,0.001302998,0.00002641937,0.007032663],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001314688,"threshold_uncertainty_score":0.004398108,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009461784877711855,"score_gpt":0.2263211436238453,"score_spread":0.2168593587461334,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}