{"id":"W2076100327","doi":"10.1182/blood-2008-09-179630","title":"FAS-L, IL-10, and double-negative CD4- CD8- TCR alpha/beta+ T cells are reliable markers of autoimmune lymphoproliferative syndrome (ALPS) associated with FAS loss of function.","year":2009,"lang":"en","type":"preprint","venue":"PubMed","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":124,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Institut National de la Santé et de la Recherche Médicale","keywords":"Autoimmune lymphoproliferative syndrome; Hypergammaglobulinemia; CD8; Immunology; Apoptosis; Cytotoxic T cell; Autoimmunity; Fas receptor; T cell; Lymphoproliferative disorders; In vitro; Biology; Molecular biology; Antigen; Immune system; Antibody; Programmed cell death; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001746509,0.0004999418,0.0001987009,0.00109014,0.00009872741,0.0003764739,0.000112913,0.0003139045,0.002598973],"category_scores_gemma":[0.0007411177,0.0001041183,0.00009949198,0.000318721,0.0002890658,0.0001787215,0.0001680083,0.0004231209,0.0007777861],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001825738,"about_ca_system_score_gemma":0.00009976741,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001729353,"about_ca_topic_score_gemma":0.0001979355,"domain_scores_codex":[0.9997461,0.00006867052,0.00002462773,0.00003825635,0.00009429905,0.00002797242],"domain_scores_gemma":[0.9996773,0.00008591742,0.0001162359,0.00002552233,0.00005056034,0.00004457711],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007844054,0.0001062874,0.03867223,0.0002416642,0.00003355219,0.001526996,0.000132993,0.0001001996,0.9161447,0.0002376414,0.0004018329,0.04161751],"study_design_scores_gemma":[0.0001426019,0.001644648,0.14072,0.0000757088,0.0001193658,0.02192756,0.0002931195,0.001351172,0.8152255,0.001175499,0.01730452,0.00002034308],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9720454,0.01269235,0.005774304,0.0002330793,0.0001079835,0.00008701233,0.000576874,0.0002366344,0.008246309],"genre_scores_gemma":[0.9904722,0.001761185,0.004164727,0.00007680148,0.00008687747,0.00004407634,0.0005533497,0.00001467084,0.002826146],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002598973,"threshold_uncertainty_score":0.00869441,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01669519722641661,"score_gpt":0.2165951753414617,"score_spread":0.1998999781150451,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}