{"id":"W2076120598","doi":"10.1016/j.neulet.2007.02.091","title":"Anaesthetic binding sites for etomidate and propofol on a GABAA receptor model","year":2007,"lang":"en","type":"article","venue":"Neuroscience Letters","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"Natural Sciences and Engineering Research Council of Canada; Killam Trusts","keywords":"Etomidate; GABAA receptor; Propofol; Protein subunit; Biophysics; Chemistry; Ion channel; Binding site; Transmembrane domain; Receptor; General anaesthetic; Extracellular; Pharmacology; Biochemistry; Medicine; Biology; Anesthesia; General anaesthesia","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003622472,0.0001545458,0.0001076794,0.00007164269,0.0001694637,0.00004036446,0.0002164601,0.0000597688,0.000001189739],"category_scores_gemma":[0.0001727215,0.0001383418,0.00005260558,0.000125755,0.0001848728,0.00000784354,0.00008855895,0.00009604707,0.000004914568],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001486766,"about_ca_system_score_gemma":0.00002336434,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001387096,"about_ca_topic_score_gemma":0.000002926969,"domain_scores_codex":[0.9987009,0.0000212291,0.0001610877,0.0005522306,0.0001597875,0.0004047678],"domain_scores_gemma":[0.9995424,0.00001985699,0.00007287901,0.0002407421,0.00002291065,0.000101177],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005888409,0.00003649229,0.002031227,0.000006362548,0.000001535778,3.743363e-7,0.00003659255,0.0001954502,0.993838,0.00002966201,0.002591216,0.0011742],"study_design_scores_gemma":[0.0006840709,0.0006802891,0.0004282726,0.00001189637,0.000009573616,0.00001271858,0.00003268514,0.003178774,0.9828008,0.000008100138,0.01185855,0.0002942264],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871981,0.00001624197,0.01010697,0.001967511,0.0002068231,0.0004045583,0.00001381411,0.00002100491,0.00006498781],"genre_scores_gemma":[0.9896494,0.00003080566,0.002623687,0.007304204,0.0001188113,0.00002185417,0.00001195333,0.00002493456,0.0002143564],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01103716,"threshold_uncertainty_score":0.5641415,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0221913135793244,"score_gpt":0.2909704734915844,"score_spread":0.26877915991226,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}