{"id":"W2076120598","doi":"10.1016/j.neulet.2007.02.091","title":"Anaesthetic binding sites for etomidate and propofol on a GABAA receptor model","year":2007,"lang":"en","type":"article","venue":"Neuroscience Letters","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"Natural Sciences and Engineering Research Council of Canada; Killam Trusts","keywords":"Etomidate; GABAA receptor; Propofol; Protein subunit; Biophysics; Chemistry; Ion channel; Binding site; Transmembrane domain; Receptor; General anaesthetic; Extracellular; Pharmacology; Biochemistry; Medicine; Biology; Anesthesia; General anaesthesia","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002365261,0.0004293347,0.0004038028,0.0004233916,0.0003965937,0.0004361217,0.001159315,0.0006418038,0.005090041],"category_scores_gemma":[0.000437126,0.0004224118,0.0005724448,0.0002431491,0.0002737404,0.0004755276,0.0002836729,0.0006500618,0.0006667338],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006884322,"about_ca_system_score_gemma":0.0004230665,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005048496,"about_ca_topic_score_gemma":0.003909199,"domain_scores_codex":[0.9997812,0.00006179883,0.000008804775,0.00003762062,0.00003739936,0.0000731768],"domain_scores_gemma":[0.9998251,0.00006926165,0.00003334194,0.00002201848,0.0000249148,0.00002545468],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.003810666,0.0001396922,0.0004451817,0.0001238562,0.0000506521,0.0004062494,0.0001186521,0.004666907,0.9764716,0.008172547,0.0004562643,0.005137807],"study_design_scores_gemma":[0.0003243544,0.001209235,0.004439211,0.00002741797,0.000201178,0.0008830845,0.0002012615,0.06369534,0.9196462,0.003766758,0.005514991,0.00009090298],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9783816,0.001575304,0.011597,0.0003839966,0.00006415489,0.00003283643,0.000287409,0.00008473729,0.007592949],"genre_scores_gemma":[0.9913443,0.0009438201,0.003252788,0.00006444355,0.00001092633,0.00001783291,0.0003642389,0.00003627139,0.003965282],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005090041,"threshold_uncertainty_score":0.01702785,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0221913135793244,"score_gpt":0.2909704734915844,"score_spread":0.26877915991226,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}