{"id":"W2076129476","doi":"10.1152/ajpgi.00089.2010","title":"Oxidative stress enhances IL-8 and inhibits CCL20 production from intestinal epithelial cells in response to bacterial flagellin","year":2010,"lang":"en","type":"article","venue":"American Journal of Physiology-Gastrointestinal and Liver Physiology","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Flagellin; TLR5; CCL20; Cell biology; p38 mitogen-activated protein kinases; Chemokine; Interleukin 8; Innate immune system; Biology; Interleukin 22; Signal transduction; Oxidative stress; Kinase; Immune system; Protein kinase A; TLR4; Microbiology; Chemokine receptor; TLR2; Immunology; Inflammation; Receptor; Cytokine; Interleukin; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005680514,0.000320248,0.0007275661,0.0003265116,0.0001277764,0.00001708887,0.0002425338,0.0001039627,0.0001394337],"category_scores_gemma":[0.0006704207,0.0002628194,0.00008458427,0.0002100833,0.001279761,0.0002498822,0.000163207,0.0009194823,0.0000524698],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002402457,"about_ca_system_score_gemma":0.0001257132,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000326619,"about_ca_topic_score_gemma":0.00007815466,"domain_scores_codex":[0.9972364,0.001133374,0.0006624938,0.0004784745,0.00005537389,0.0004339244],"domain_scores_gemma":[0.9978403,0.0009360274,0.0006930464,0.0002005879,0.0002454,0.00008457093],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01855698,0.0001718122,0.0004413107,0.00001117028,0.00005888116,0.00001235489,0.001110507,0.0000186023,0.9742676,0.00003473978,0.00005802001,0.005258044],"study_design_scores_gemma":[0.0009038308,0.004218222,0.2316659,0.000149876,0.00003528765,0.0005630942,0.0007182835,0.000009411525,0.7608227,0.0003362748,0.0003765485,0.0002006128],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984539,0.00009757146,0.00009297213,0.000379987,0.0007128279,0.0001926672,0.00004854159,0.00001569992,0.000005792444],"genre_scores_gemma":[0.9967875,0.00007868576,0.002531985,0.00009194492,0.0004016089,0.000009901907,0.00003418964,0.00001743102,0.00004676336],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2312246,"threshold_uncertainty_score":0.9999824,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005054568755966181,"score_gpt":0.2120876941301693,"score_spread":0.2070331253742031,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}