{"id":"W2076133821","doi":"10.1158/0008-5472.can-05-3555","title":"Recombinant Human Insulin-like Growth Factor Binding Protein 3 Inhibits Growth of Human Epidermal Growth Factor Receptor-2–Overexpressing Breast Tumors and Potentiates Herceptin Activity <i>In vivo</i>","year":2006,"lang":"en","type":"article","venue":"Cancer Research","topic":"Growth Hormone and Insulin-like Growth Factors","field":"Medicine","cited_by":103,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Cancer research; MAPK/ERK pathway; Epidermal growth factor receptor; Protein kinase B; SKBR3; Growth factor receptor; Growth factor; Trastuzumab; Epidermal growth factor; Biology; Tyrosine kinase; Phosphorylation; Signal transduction; Endocrinology; Internal medicine; Breast cancer; Receptor; Cancer; Medicine; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001234019,0.000760276,0.001375934,0.00151387,0.0008056244,0.0001855947,0.0005048604,0.000511749,0.0006397488],"category_scores_gemma":[0.0002943526,0.0007010901,0.0002770366,0.001749785,0.0008614657,0.0009770041,0.0004893428,0.001996665,0.00002158725],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009015388,"about_ca_system_score_gemma":0.0004864489,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01615633,"about_ca_topic_score_gemma":0.0003801209,"domain_scores_codex":[0.9929857,0.000787696,0.001309977,0.001397226,0.001683288,0.001836171],"domain_scores_gemma":[0.9970706,0.000211893,0.000503053,0.0005990346,0.001022317,0.0005931199],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005050547,0.0006616365,0.1776436,0.001056343,0.00006458852,0.00005183461,0.0005144612,2.844477e-7,0.8172257,0.0003698093,0.001302426,0.0006043039],"study_design_scores_gemma":[0.003544464,0.0006673256,0.3175251,0.001593351,0.00002508932,0.0000324451,0.0002270952,0.000009201286,0.6752365,0.0005042594,0.00006084684,0.000574398],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947817,0.0004990379,0.000008560698,0.000798039,0.0001799863,0.001994782,0.0004097919,0.0001349603,0.001193098],"genre_scores_gemma":[0.9973779,0.0002224505,0.0001302803,0.00004528037,0.0003637845,0.0002360615,0.00008258686,0.0001855008,0.001356133],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1419892,"threshold_uncertainty_score":0.999544,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04601694629739068,"score_gpt":0.3298142238510243,"score_spread":0.2837972775536336,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}