{"id":"W2076133821","doi":"10.1158/0008-5472.can-05-3555","title":"Recombinant Human Insulin-like Growth Factor Binding Protein 3 Inhibits Growth of Human Epidermal Growth Factor Receptor-2–Overexpressing Breast Tumors and Potentiates Herceptin Activity <i>In vivo</i>","year":2006,"lang":"en","type":"article","venue":"Cancer Research","topic":"Growth Hormone and Insulin-like Growth Factors","field":"Medicine","cited_by":103,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Cancer research; MAPK/ERK pathway; Epidermal growth factor receptor; Protein kinase B; SKBR3; Growth factor receptor; Growth factor; Trastuzumab; Epidermal growth factor; Biology; Tyrosine kinase; Phosphorylation; Signal transduction; Endocrinology; Internal medicine; Breast cancer; Receptor; Cancer; Medicine; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001645869,0.0004252059,0.000293515,0.0001954627,0.00007646664,0.0002088612,0.0001241313,0.0001386322,0.0007591828],"category_scores_gemma":[0.00009588144,0.00009542274,0.0002555977,0.0001006974,0.000147224,0.00009847018,0.00007112805,0.0006022129,0.0002417601],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002536879,"about_ca_system_score_gemma":0.0001774906,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006398975,"about_ca_topic_score_gemma":0.001354324,"domain_scores_codex":[0.9999062,0.00002234784,0.000005700649,0.000008462004,0.00002840246,0.00002888035],"domain_scores_gemma":[0.9999614,0.000008405093,0.000009588506,0.000004338289,0.000003446145,0.00001286024],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004282076,0.0002228442,0.0002910247,0.00003735102,0.00001103512,0.00003783306,0.000008641011,0.0001287906,0.9949166,0.0000428142,0.0001164319,0.00375856],"study_design_scores_gemma":[0.0001283618,0.003471288,0.0078905,0.000005196284,0.00002829921,0.000394316,0.00001167382,0.001037485,0.9840878,0.00003332198,0.002906922,0.000004988119],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937244,0.001994103,0.001504465,0.0001355672,0.00004264244,0.0000469824,0.0002050209,0.0001195402,0.002227156],"genre_scores_gemma":[0.9945771,0.001269384,0.002037939,0.00007703752,0.00002615012,0.00003349708,0.000544138,0.00002367709,0.001411089],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007591828,"threshold_uncertainty_score":0.002539754,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04601694629739068,"score_gpt":0.3298142238510243,"score_spread":0.2837972775536336,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}