{"id":"W2076143306","doi":"10.1016/s0303-7207(01)00402-6","title":"Interplay of pituitary adenylate cyclase-activating polypeptide with a silencer element to regulate the upstream promoter of the human gonadotropin-releasing hormone receptor gene","year":2001,"lang":"en","type":"article","venue":"Molecular and Cellular Endocrinology","topic":"Hypothalamic control of reproductive hormones","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Medical Research Council; Hong Kong Government","keywords":"Pituitary adenylate cyclase-activating peptide; Forskolin; Biology; Hormone response element; Promoter; Gonadotropic cell; Response element; Anterior pituitary; Receptor; Reporter gene; Cell biology; Silencer; Molecular biology; Endocrinology; Internal medicine; Gene; Vasoactive intestinal peptide; Gene expression; Hormone; Pituitary gland; Biochemistry; Neuropeptide; Genetics; Estrogen receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004130058,0.000330279,0.000291177,0.0002237014,0.0002477778,0.0005437697,0.0003431402,0.000328914,0.001786681],"category_scores_gemma":[0.0004430706,0.0002058584,0.0002759189,0.00009735778,0.0006375986,0.0002459691,0.0003860605,0.0006469977,0.0004124246],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004766208,"about_ca_system_score_gemma":0.0004213706,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000652143,"about_ca_topic_score_gemma":0.001095114,"domain_scores_codex":[0.9997234,0.00004875906,0.00001516524,0.00007288938,0.00006154858,0.00007835364],"domain_scores_gemma":[0.9997441,0.0001052542,0.00003499218,0.00002975253,0.00001984461,0.00006594545],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001509017,0.00002049049,0.0001488718,0.00001660846,0.000005042135,0.00008284162,0.00002639941,0.00009499541,0.9979228,0.0006248177,0.00004508636,0.0008612379],"study_design_scores_gemma":[0.0001316718,0.0003145374,0.00587339,0.00001628048,0.00005367329,0.0004284518,0.0001818773,0.007094529,0.9791619,0.0008419464,0.005884051,0.00001767712],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863645,0.002130524,0.00607121,0.000493019,0.0001727815,0.00002602954,0.000150729,0.00009444953,0.004496734],"genre_scores_gemma":[0.996347,0.0002696599,0.001508761,0.0001541678,0.00002545747,0.0000136462,0.000168716,0.00003825671,0.001474423],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001786681,"threshold_uncertainty_score":0.005977035,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007848326810209595,"score_gpt":0.2379129184446168,"score_spread":0.2300645916344072,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}