{"id":"W2076154138","doi":"10.1038/nature14248","title":"Integrative analysis of 111 reference human epigenomes","year":2015,"lang":"en","type":"article","venue":"Nature","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7110,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; University of British Columbia; Canada's Michael Smith Genome Sciences Centre; BC Cancer Agency","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; Common Fund; National Institute of Environmental Health Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute on Deafness and Other Communication Disorders; National Institute on Drug Abuse; National Institute of Mental Health; National Heart, Lung, and Blood Institute; National Institute on Aging; Tsinghua National Laboratory for Information Science and Technology; National Center for Advancing Translational Sciences; National Human Genome Research Institute; Tsinghua University; National Natural Science Foundation of China; National Institutes of Health; National Science Foundation; Washington University in St. Louis; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; Massachusetts General Hospital; Howard Hughes Medical Institute","keywords":"Epigenomics; DNA methylation; Computational biology; Biology; Human genome; Genetics; Epigenome; Chromatin; Genome; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001143819,0.0004691878,0.0008789288,0.002176328,0.0004042729,0.0007580416,0.0004928918,0.0003018064,0.002816617],"category_scores_gemma":[0.002418736,0.0003301785,0.00124618,0.003029544,0.0002193561,0.0003031557,0.001223075,0.0006270165,0.0009568913],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004740526,"about_ca_system_score_gemma":0.0006356842,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002953024,"about_ca_topic_score_gemma":0.005369241,"domain_scores_codex":[0.9988403,0.0002275585,0.000065179,0.0004233029,0.0003252092,0.0001185964],"domain_scores_gemma":[0.9989349,0.0003144965,0.00009923687,0.000278947,0.0002938494,0.00007848419],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002108729,0.0001887585,0.06801657,0.001750448,0.00145381,0.001076917,0.001481873,0.01004735,0.6552163,0.007544203,0.007065451,0.2440496],"study_design_scores_gemma":[0.0001910762,0.0006743583,0.5883796,0.0002708666,0.00163591,0.002539713,0.0007420371,0.01615047,0.2353733,0.008337316,0.145556,0.0001493555],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6267311,0.007834908,0.2435332,0.0004422836,0.0001233328,0.0007250379,0.09892154,0.002170202,0.0195184],"genre_scores_gemma":[0.5168983,0.004142919,0.2156807,0.0003728227,0.00006258908,0.0007560074,0.2553989,0.001125985,0.005561702],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002953024,"threshold_uncertainty_score":0.009422541,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02391063745499477,"score_gpt":0.3307579090249536,"score_spread":0.3068472715699588,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}