{"id":"W2076168873","doi":"10.1161/circulationaha.113.006167","title":"Role for DNA Damage Signaling in Pulmonary Arterial Hypertension","year":2013,"lang":"en","type":"article","venue":"Circulation","topic":"Pulmonary Hypertension Research and Treatments","field":"Medicine","cited_by":256,"is_retracted":false,"has_abstract":true,"ca_institutions":"SNC-Lavalin (Canada)","funders":"Canadian Institutes of Health Research; Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval","keywords":"DNA damage; Poly ADP ribose polymerase; Cancer research; Apoptosis; Terminal deoxynucleotidyl transferase; Molecular biology; PARP inhibitor; Transcription factor; Tumor necrosis factor alpha; Proliferating cell nuclear antigen; DNA repair; Medicine; Biology; Pathology; Immunology; DNA; Polymerase; TUNEL assay; Immunohistochemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008832326,0.00009252311,0.0001728675,0.0002629431,0.00006224308,0.00001869875,0.00003211738,0.00007619669,0.000158136],"category_scores_gemma":[0.00008171433,0.0000785296,0.00006153624,0.0002352834,0.00001834666,0.0001835355,0.00001438523,0.00006548983,0.0001221499],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005993717,"about_ca_system_score_gemma":0.00003977006,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008060983,"about_ca_topic_score_gemma":0.00000214569,"domain_scores_codex":[0.9991751,0.00002723946,0.0001769004,0.0002168864,0.0001775049,0.0002263308],"domain_scores_gemma":[0.9995015,0.00005681748,0.00003155586,0.0001652671,0.0001295639,0.0001153042],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001515997,0.0003089656,0.08281123,0.0000277994,0.00001599579,0.0001390293,0.00001723026,0.00003727103,0.9074636,0.00001953257,0.0001095,0.008898257],"study_design_scores_gemma":[0.001579133,0.00006490091,0.9452388,0.00006166769,0.00002107603,0.00008508651,0.0000618674,0.0479719,0.00334654,0.001309659,0.0001808256,0.00007849201],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975843,0.00009985637,0.00007651028,0.000512442,0.0000688912,0.00102219,0.000003814461,0.00003427265,0.0005976684],"genre_scores_gemma":[0.998736,0.000005164705,0.0004347041,0.0002011043,0.0001367529,0.0001402363,0.0002481903,0.00001727209,0.00008063851],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.904117,"threshold_uncertainty_score":0.3202344,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0320106592987908,"score_gpt":0.2724902188645312,"score_spread":0.2404795595657404,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}