{"id":"W2076196501","doi":"10.1021/bi700281x","title":"Probing the Promiscuous Active Site of <i>myo</i>-Inositol Dehydrogenase Using Synthetic Substrates, Homology Modeling, and Active Site Modification","year":2007,"lang":"en","type":"article","venue":"Biochemistry","topic":"Cassava research and cyanide","field":"Agricultural and Biological Sciences","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Active site; Stereochemistry; Chemistry; Oxidoreductase; Dehydrogenase; Inositol; Histidine; NAD+ kinase; Binding site; Enzyme; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001492797,0.0004133642,0.0003409206,0.0001026219,0.0001615472,0.0005452321,0.0006600822,0.0004530671,0.0005557683],"category_scores_gemma":[0.0001988655,0.0002091958,0.0003552066,0.0001864736,0.0002543549,0.0002529607,0.0001871343,0.0007091478,0.0002718164],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006013907,"about_ca_system_score_gemma":0.000326763,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00121528,"about_ca_topic_score_gemma":0.001080314,"domain_scores_codex":[0.9999158,0.00001649777,0.000004882343,0.00001836862,0.00003191323,0.00001249906],"domain_scores_gemma":[0.9999405,0.00002062415,0.00001732052,0.000004639441,0.000006030245,0.00001088698],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004621767,0.0002383078,0.001786695,0.0002416,0.00003683611,0.0003970845,0.0001208186,0.06001545,0.9267995,0.003555604,0.0001949926,0.00615101],"study_design_scores_gemma":[0.00009548868,0.0003712653,0.001655402,0.00001994204,0.00004216576,0.000368672,0.0001514433,0.285776,0.7062617,0.0007669764,0.00446004,0.00003085422],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.979675,0.0005638505,0.01811238,0.000107339,0.00001143376,0.00003114467,0.0003029653,0.000125353,0.001070637],"genre_scores_gemma":[0.9768687,0.0007654776,0.02112399,0.00002875384,0.000003832612,0.00004437477,0.0006526443,0.00002910721,0.0004831772],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00121528,"threshold_uncertainty_score":0.004363477,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03048192001027739,"score_gpt":0.2614335706917997,"score_spread":0.2309516506815223,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}