{"id":"W2076213451","doi":"10.1136/ard.2005.041855","title":"PD-0200347, an α2δ ligand of the voltage gated calcium channel, inhibits in vivo activation of the Erk1/2 pathway in osteoarthritic chondrocytes: a PKCα dependent effect","year":2005,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Hôpital Notre-Dame","funders":"Pfizer","keywords":"Medicine; In vivo; p38 mitogen-activated protein kinases; Phosphorylation; Cartilage; Kinase; CREB; Protein kinase C; Internal medicine; Signal transduction; Endocrinology; Osteoarthritis; Cell biology; Protein kinase A; Anatomy; Transcription factor; Chemistry; Biology; Pathology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002177601,0.0007000757,0.0005609511,0.0003820085,0.0002595391,0.0003501546,0.0003567816,0.0004320246,0.00203347],"category_scores_gemma":[0.0002073854,0.0002449368,0.0004846439,0.000251803,0.0003999179,0.000245827,0.0001878175,0.001585988,0.0007231698],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003075832,"about_ca_system_score_gemma":0.000680541,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008728764,"about_ca_topic_score_gemma":0.001678724,"domain_scores_codex":[0.9998255,0.00003564341,0.0000160606,0.00001120131,0.00003713744,0.00007439303],"domain_scores_gemma":[0.9998831,0.0000225359,0.00002605377,0.00001762547,0.000009426174,0.00004130145],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004888494,0.001058207,0.0003099104,0.0001401539,0.00003794667,0.0001669145,0.00003226504,0.0002808769,0.9860694,0.0001786965,0.0005836255,0.00625346],"study_design_scores_gemma":[0.002010278,0.006681728,0.005713748,0.00001682894,0.00006758366,0.0004360669,0.00007865446,0.001927491,0.9808621,0.000133808,0.002057246,0.00001462391],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947172,0.001446563,0.0009472083,0.0003083528,0.00009948792,0.00005543492,0.0002927427,0.0001554494,0.001977572],"genre_scores_gemma":[0.9934253,0.001510894,0.0007183676,0.00009553128,0.00003718831,0.00008841445,0.0007063999,0.00001880721,0.00339916],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00203347,"threshold_uncertainty_score":0.006802619,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02248172817343663,"score_gpt":0.278079485809335,"score_spread":0.2555977576358984,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}