{"id":"W2076229197","doi":"10.1074/jbc.m309805200","title":"The MEK-ERK Signaling Pathway Is a Negative Regulator of Cartilage-specific Gene Expression in Embryonic Limb Mesenchyme","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada; Directorate for Biological Sciences; University of Connecticut","keywords":"Mesenchyme; Regulator; Cell biology; Embryonic stem cell; Limb development; MAPK/ERK pathway; Zone of polarizing activity; Cartilage; Limb bud; Biology; Signal transduction; Mesoderm; Anatomy; Gene; Embryo; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008638268,0.0003688564,0.0001808219,0.0001845189,0.000201199,0.0002506344,0.0001378923,0.0001228,0.001060597],"category_scores_gemma":[0.00006476972,0.000153115,0.0002164264,0.00009451578,0.0001351939,0.0001309756,0.0001946852,0.0003694387,0.0004142545],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002441532,"about_ca_system_score_gemma":0.0002582683,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005702961,"about_ca_topic_score_gemma":0.0008028287,"domain_scores_codex":[0.9999028,0.00001036408,0.000009312587,0.00002132002,0.00003510209,0.00002110468],"domain_scores_gemma":[0.9999611,0.000004391427,0.00001241837,0.000002662042,0.0000099017,0.000009508959],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001388024,0.000018475,0.0006427836,0.0001456228,0.00001029089,0.0001287667,0.00001503372,0.0001368711,0.9930079,0.000337428,0.0001183035,0.00529974],"study_design_scores_gemma":[0.00002090792,0.0001607281,0.02566416,0.0000175504,0.00002568444,0.0009943402,0.00003470584,0.00224874,0.9594094,0.0002000486,0.01121389,0.000009906087],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9627432,0.01317999,0.01471577,0.0002459525,0.00009776802,0.00005814375,0.001191304,0.000315516,0.007452284],"genre_scores_gemma":[0.9840294,0.004280216,0.004311057,0.00005612339,0.0000159695,0.00004248141,0.0007252832,0.00001668244,0.006522783],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001060597,"threshold_uncertainty_score":0.003548086,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02395756105904061,"score_gpt":0.2469348495635362,"score_spread":0.2229772885044956,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}