{"id":"W2076236539","doi":"10.1021/bi0024456","title":"Phospholipid Flippase Activity of the Reconstituted P-Glycoprotein Multidrug Transporter","year":2001,"lang":"en","type":"article","venue":"Biochemistry","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":157,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"","keywords":"Flippase; Phosphatidylserine; Phosphatidylethanolamine; ATP-binding cassette transporter; Chemistry; Biochemistry; Phospholipid; Lipid bilayer; Phosphatidylcholine; Sphingomyelin; P-glycoprotein; Efflux; Biophysics; Transporter; Membrane; Biology; Multiple drug resistance","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009266417,0.0001556341,0.0002450627,0.00001723107,0.00005866086,0.00000376925,0.0001379789,0.0001497434,0.0003410892],"category_scores_gemma":[0.00001669795,0.0001050119,0.0002154082,0.0001878766,0.0001715796,0.00003155522,0.000009539373,0.0001984667,0.000006727599],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003695088,"about_ca_system_score_gemma":0.0001520585,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004653679,"about_ca_topic_score_gemma":0.00001348308,"domain_scores_codex":[0.9991026,0.000007701385,0.0002131278,0.0002411114,0.0002329604,0.0002024802],"domain_scores_gemma":[0.9992365,0.00000875204,0.0000959778,0.0004968459,0.00005719054,0.0001046954],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004091344,0.0002592224,0.006411503,0.0002012473,0.00004266867,0.00005452166,0.00006225278,0.000001084931,0.9887356,0.00001225857,0.0003098403,0.003500733],"study_design_scores_gemma":[0.001153019,0.00001797532,0.01235296,0.0002248912,0.00008105509,0.00005805945,0.0000412496,0.0000251189,0.9804274,0.0000140934,0.00548403,0.0001201757],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934627,0.0001685864,0.0002425726,0.0007275933,0.0002567391,0.0002809587,0.00002904248,0.00004832465,0.004783444],"genre_scores_gemma":[0.9931965,0.00005746233,0.0004090675,0.0001089239,0.0001150667,0.00001765157,0.00001953444,0.0000158577,0.006059883],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008308156,"threshold_uncertainty_score":0.4282262,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00943964867585957,"score_gpt":0.2241276032324908,"score_spread":0.2146879545566313,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}