{"id":"W2076236539","doi":"10.1021/bi0024456","title":"Phospholipid Flippase Activity of the Reconstituted P-Glycoprotein Multidrug Transporter","year":2001,"lang":"en","type":"article","venue":"Biochemistry","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":157,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"","keywords":"Flippase; Phosphatidylserine; Phosphatidylethanolamine; ATP-binding cassette transporter; Chemistry; Biochemistry; Phospholipid; Lipid bilayer; Phosphatidylcholine; Sphingomyelin; P-glycoprotein; Efflux; Biophysics; Transporter; Membrane; Biology; Multiple drug resistance","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001767623,0.0002915557,0.0002575562,0.0001106774,0.0001079195,0.000316373,0.0001926409,0.0002607288,0.0006496122],"category_scores_gemma":[0.0003310409,0.0001105983,0.000167014,0.0001148332,0.0002110746,0.0003887037,0.0001900401,0.0005455922,0.0002435057],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004116193,"about_ca_system_score_gemma":0.0001871976,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008345892,"about_ca_topic_score_gemma":0.0005766343,"domain_scores_codex":[0.9998385,0.00004055059,0.00001616101,0.0000306214,0.00004667549,0.00002745114],"domain_scores_gemma":[0.9998859,0.00003463484,0.00002315616,0.00001655445,0.00002416956,0.00001555452],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005715001,0.00001258149,0.00009747314,0.00001613371,0.000004207683,0.00002667636,0.00001463511,0.00004986067,0.9992943,0.00006774045,0.00001096888,0.0003482573],"study_design_scores_gemma":[0.00001437147,0.0001377165,0.001026549,0.000004677258,0.000009595564,0.00008876583,0.00001351317,0.001877251,0.9962858,0.00004188933,0.0004956998,0.00000407778],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960741,0.0006297758,0.002387325,0.00007304068,0.0000224285,0.00001125707,0.0002139446,0.00002902079,0.0005591527],"genre_scores_gemma":[0.9938936,0.0005240071,0.003031628,0.00003395898,0.00001129138,0.0000201966,0.0009819799,0.00002154112,0.001481841],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008345892,"threshold_uncertainty_score":0.002986491,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00943964867585957,"score_gpt":0.2241276032324908,"score_spread":0.2146879545566313,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}