{"id":"W2076252370","doi":"10.1074/jbc.m107928200","title":"Structural and Functional Asymmetry of the Nucleotide-binding Domains of P-glycoprotein Investigated by Attenuated Total Reflection Fourier Transform Infrared Spectroscopy","year":2002,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Attenuated total reflection; Fourier transform; Fourier transform infrared spectroscopy; Infrared; Asymmetry; Glycoprotein; Reflection (computer programming); Infrared spectroscopy; Chemistry; Spectroscopy; Biochemistry; Optics; Physics; Computer science; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001930703,0.0001957329,0.0001170579,0.0001209477,0.0000779976,0.0001467795,0.0001940619,0.0002574945,0.0004224199],"category_scores_gemma":[0.0003358889,0.0001210148,0.0001501509,0.0001112778,0.0002672735,0.0002984699,0.00008727291,0.0005110616,0.00009461534],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001165471,"about_ca_system_score_gemma":0.00008725395,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003611099,"about_ca_topic_score_gemma":0.0001659081,"domain_scores_codex":[0.9999123,0.00002260141,0.00000375326,0.00001412311,0.00003296816,0.00001424412],"domain_scores_gemma":[0.999837,0.00005270328,0.00005754182,0.00001317601,0.00002102458,0.00001847096],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004657385,0.000007513104,0.0001936877,0.000006524722,0.000001736204,0.00003152998,0.00001287983,0.0001042158,0.9990189,0.00007391396,0.000006522395,0.0004959827],"study_design_scores_gemma":[0.00002630578,0.0002537088,0.01566617,0.000004456168,0.00002034596,0.0007847975,0.00007098566,0.01233001,0.9696966,0.0003442804,0.0007861447,0.0000161325],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970028,0.0001472616,0.002449166,0.00003314111,0.000002211257,0.000004031873,0.00003744234,0.00001119692,0.0003127244],"genre_scores_gemma":[0.9975611,0.0001269467,0.002014639,0.00001550483,0.000001703733,0.000006540364,0.00007835861,0.000006615036,0.0001885953],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004224199,"threshold_uncertainty_score":0.001413107,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02098866974355329,"score_gpt":0.232083608490335,"score_spread":0.2110949387467817,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}