{"id":"W2076257690","doi":"10.1186/s12864-015-1518-0","title":"The pathogenic human Torsin A in Drosophila activates the unfolded protein response and increases susceptibility to oxidative stress","year":2015,"lang":"en","type":"article","venue":"BMC Genomics","topic":"Neurological disorders and treatments","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"National Institute of General Medical Sciences; Ministry of Education, Science and Technology; National Research Foundation; Korea Basic Science Institute; Rural Development Administration; National Research Foundation of Korea; Howard Hughes Medical Institute","keywords":"Unfolded protein response; Endoplasmic reticulum; Biology; XBP1; Cell biology; Heat shock protein; Drosophila melanogaster; Chaperone (clinical); Heat shock; Hsp70; Endoplasmic-reticulum-associated protein degradation; Autophagy; Molecular biology; Biochemistry; Gene; RNA splicing; RNA; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007462024,0.0004133062,0.0001261813,0.000271661,0.000177463,0.0001579352,0.0001081798,0.0002990678,0.001335515],"category_scores_gemma":[0.00007860479,0.0001179161,0.0001645676,0.0001157888,0.0002107401,0.0001173487,0.0001901296,0.0002608576,0.0002652288],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002933004,"about_ca_system_score_gemma":0.000116512,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005457615,"about_ca_topic_score_gemma":0.001037759,"domain_scores_codex":[0.9999233,0.0000111992,0.0000104773,0.00002540416,0.00001818496,0.00001128809],"domain_scores_gemma":[0.9999149,0.00001010878,0.00004298972,0.000005661667,0.000007410682,0.00001893964],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005630397,0.000006826344,0.0003418609,0.00003729057,0.000005853617,0.0001359012,0.000005066705,0.00001977777,0.9988218,0.0000239886,0.00004479775,0.0005004876],"study_design_scores_gemma":[0.00004781633,0.0003370978,0.07551952,0.00005073041,0.00007133125,0.003981536,0.0001117779,0.001183771,0.9135771,0.0001142083,0.004990399,0.00001474711],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950882,0.001391807,0.001139931,0.0001108708,0.00002482073,0.00003204059,0.001342913,0.00006356955,0.000805873],"genre_scores_gemma":[0.9945925,0.0008459349,0.001705221,0.0001012554,0.000008892714,0.00003137489,0.001152938,0.00001998193,0.001541985],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001335515,"threshold_uncertainty_score":0.004467726,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04525875247053694,"score_gpt":0.2938731634941744,"score_spread":0.2486144110236374,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}