{"id":"W2076265633","doi":"10.1158/1538-7445.am2012-993","title":"Abstract 993: A high-throughput peptide array screen of H3K9 methyl effectors identifies UHRF1 as an exception to the “phospho/methyl switch.”","year":2012,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Chromatin; Histone; Cell biology; Mitosis; DNA methylation; Ubiquitin ligase; Biology; Methylation; Effector; Histone H3; Epigenetics; Chromatin immunoprecipitation; Molecular biology; Chemistry; DNA; Ubiquitin; Genetics; Gene expression; Promoter; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002556725,0.0004294853,0.0003846701,0.0003563717,0.0002051749,0.0003207998,0.0003420269,0.0004423393,0.001568777],"category_scores_gemma":[0.0002128871,0.0001639946,0.0003542681,0.0003899342,0.0001573666,0.0001217423,0.0002411339,0.0003117479,0.000889562],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001988526,"about_ca_system_score_gemma":0.0001510078,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005291142,"about_ca_topic_score_gemma":0.0009896415,"domain_scores_codex":[0.9997912,0.00001852764,0.00001332225,0.00006039936,0.00007828523,0.00003819711],"domain_scores_gemma":[0.9998614,0.0000338313,0.00003086501,0.00001482499,0.00001946269,0.00003964778],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001142837,0.00002870051,0.001079679,0.00001862473,0.00001371393,0.00007321659,0.000004502828,0.00007654345,0.9966426,0.00001580591,0.00009757032,0.001834728],"study_design_scores_gemma":[0.00002859682,0.0006214128,0.02945753,0.000004121162,0.00006743446,0.001001339,0.00002064505,0.001362902,0.9652894,0.00004050305,0.002094203,0.00001189251],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9817694,0.001231287,0.00791987,0.0001428636,0.0000279561,0.000165528,0.006282493,0.0004253174,0.002035208],"genre_scores_gemma":[0.9760909,0.0003946839,0.0109779,0.0001967174,0.0000153615,0.00007424906,0.009049525,0.00008632935,0.003114337],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001568777,"threshold_uncertainty_score":0.00524801,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03964804355172034,"score_gpt":0.3914433972625757,"score_spread":0.3517953537108554,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}