{"id":"W2076271925","doi":"10.1038/onc.2012.460","title":"A human monoclonal antibody 264RAD targeting αvβ6 integrin reduces tumour growth and metastasis, and modulates key biomarkers in vivo","year":2012,"lang":"en","type":"article","venue":"Oncogene","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":86,"is_retracted":false,"has_abstract":false,"ca_institutions":"Amgen (Canada)","funders":"Medical Research Council","keywords":"Biology; Monoclonal antibody; In vivo; Metastasis; Integrin; Cancer research; Immunology; Antibody; Cancer; Cell; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007075035,0.0002119954,0.0003668132,0.0003406311,0.0001009809,0.00003784413,0.00008893768,0.00009405735,0.0001560191],"category_scores_gemma":[0.0002188893,0.000179058,0.00005600813,0.0002999842,0.0001545754,0.0001401113,0.0001917872,0.0002544977,0.00000853815],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005991245,"about_ca_system_score_gemma":0.00005140701,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004028266,"about_ca_topic_score_gemma":0.00001514788,"domain_scores_codex":[0.9983271,0.0001351372,0.0003222067,0.0003601196,0.0003395471,0.0005159046],"domain_scores_gemma":[0.9992967,0.00007701042,0.00007228123,0.0001306584,0.00005794904,0.0003654341],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008735099,0.0001531817,0.07890214,0.0001032873,0.00009587876,0.00007292977,0.0003181318,3.757374e-7,0.9179931,0.00007042777,0.0003290814,0.001874115],"study_design_scores_gemma":[0.001370133,0.0002086756,0.05482659,0.0001253056,0.00006370704,0.0001433534,0.0005576256,0.0003227308,0.9413696,0.00007206912,0.0007151366,0.0002250823],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904984,0.007007758,0.00001731999,0.0005395167,0.00004495832,0.0003073848,0.00001248067,0.00002922394,0.001542977],"genre_scores_gemma":[0.994446,0.0005632098,0.004533553,0.00006076903,0.0001389802,0.00001527804,0.00003303307,0.000037122,0.0001720187],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02407555,"threshold_uncertainty_score":0.7301773,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02552976738051185,"score_gpt":0.3334568302682014,"score_spread":0.3079270628876896,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}