{"id":"W2076271925","doi":"10.1038/onc.2012.460","title":"A human monoclonal antibody 264RAD targeting αvβ6 integrin reduces tumour growth and metastasis, and modulates key biomarkers in vivo","year":2012,"lang":"en","type":"article","venue":"Oncogene","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":86,"is_retracted":false,"has_abstract":false,"ca_institutions":"Amgen (Canada)","funders":"Medical Research Council","keywords":"Biology; Monoclonal antibody; In vivo; Metastasis; Integrin; Cancer research; Immunology; Antibody; Cancer; Cell; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003387809,0.0005513603,0.0005236529,0.0005301266,0.0002259265,0.000439355,0.0005244543,0.0006011411,0.002198467],"category_scores_gemma":[0.0002471836,0.0003136476,0.0003926344,0.0003006361,0.000365241,0.0003197701,0.0001826026,0.001157292,0.0006992699],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004004897,"about_ca_system_score_gemma":0.000442142,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001066439,"about_ca_topic_score_gemma":0.001079217,"domain_scores_codex":[0.9997184,0.00004984726,0.0000166404,0.00004474975,0.00004836692,0.0001219117],"domain_scores_gemma":[0.9998332,0.0000406025,0.0000346058,0.00003017791,0.00001741359,0.00004405103],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006990729,0.0002898382,0.0001581977,0.00003600241,0.00002010811,0.00004063415,0.0000124097,0.0001209768,0.9959772,0.0001641966,0.0001906106,0.002290832],"study_design_scores_gemma":[0.0001535528,0.002391941,0.00200523,0.000007625857,0.00007342362,0.0003251441,0.00002594108,0.00114336,0.9912082,0.00009307729,0.002565306,0.000007213615],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912512,0.00244986,0.003119928,0.0003123874,0.0001074653,0.00004025184,0.0001924214,0.0002269706,0.002299613],"genre_scores_gemma":[0.9890407,0.001301809,0.002256228,0.0001055567,0.00005601177,0.00004121338,0.0008359706,0.00005133443,0.006311089],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002198467,"threshold_uncertainty_score":0.007354558,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02552976738051185,"score_gpt":0.3334568302682014,"score_spread":0.3079270628876896,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}