{"id":"W2076273188","doi":"10.1242/jcs.003335","title":"Metalloproteinase axes increase β-catenin signaling in primary mouse mammary epithelial cells lacking TIMP3","year":2007,"lang":"en","type":"article","venue":"Journal of Cell Science","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research","funders":"","keywords":"Biology; Cyclin D1; Wnt signaling pathway; Beta-catenin; Morphogenesis; Cell biology; Catenin; Cancer research; Molecular biology; Signal transduction; Cell; Gene; Cell cycle; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001872192,0.0005927365,0.0002924739,0.0003821197,0.000148375,0.0004433019,0.0002133201,0.000291419,0.002936158],"category_scores_gemma":[0.0001394566,0.0002502416,0.000501418,0.0002418892,0.0002271778,0.0002369093,0.0002242998,0.0009710505,0.0009145435],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003760475,"about_ca_system_score_gemma":0.0002512759,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007166158,"about_ca_topic_score_gemma":0.001006821,"domain_scores_codex":[0.9997566,0.00002925522,0.00003691311,0.00004611253,0.00007264503,0.00005835399],"domain_scores_gemma":[0.9996724,0.00005594347,0.00011085,0.0000453347,0.00002950112,0.0000859442],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004362476,0.0000089736,0.00006452845,0.00001210894,0.000002115272,0.00002642674,0.000004332026,0.000007044789,0.9996137,0.00002107406,0.00001599063,0.0001800921],"study_design_scores_gemma":[0.00001056153,0.00009752673,0.002379372,0.000003642937,0.000009819714,0.0001856775,0.00001479776,0.0001821978,0.9959323,0.00002132992,0.001160808,0.000002027476],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891902,0.002575555,0.003264679,0.0002214503,0.00008447027,0.00004505613,0.002165356,0.0003912431,0.00206213],"genre_scores_gemma":[0.9858428,0.001529075,0.003464166,0.0001301979,0.00002461503,0.00008101729,0.002591211,0.00009287579,0.006244038],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002936158,"threshold_uncertainty_score":0.009822428,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006070284954612353,"score_gpt":0.2285574498576034,"score_spread":0.222487164902991,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}