{"id":"W2076280550","doi":"10.1152/ajpgi.00054.2011","title":"Polyamines mediate glutamine-dependent induction of the intestinal epithelial heat shock response","year":2011,"lang":"en","type":"article","venue":"American Journal of Physiology-Gastrointestinal and Liver Physiology","topic":"Polyamine Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute","keywords":"Spermidine; Ornithine decarboxylase; Glutamine; Spermine; Polyamine; Putrescine; Biology; Heat shock protein; Hsp70; Biochemistry; Heat shock; Ornithine decarboxylase antizyme; Ornithine; Cell biology; Molecular biology; Enzyme; Arginine; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002764587,0.0002319471,0.0004355361,0.0000913888,0.0001014898,0.000003806561,0.0004271224,0.00004960896,0.00002190525],"category_scores_gemma":[0.0002735567,0.0001548062,0.0001797059,0.000171001,0.001407872,0.00001394134,0.0002448887,0.0002684518,0.000002927068],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001010584,"about_ca_system_score_gemma":0.0001280926,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000153869,"about_ca_topic_score_gemma":0.000008569375,"domain_scores_codex":[0.9983741,0.0004326037,0.0004862052,0.0002955687,0.0001208254,0.0002907074],"domain_scores_gemma":[0.9985973,0.0001022029,0.0006033429,0.0003182807,0.0002585498,0.00012034],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002309829,0.000166926,0.002021721,0.00001026026,0.00004923718,0.000002173975,0.0001304615,0.00001877587,0.9932386,0.00009914348,0.00006667723,0.001886229],"study_design_scores_gemma":[0.0006267295,0.003927914,0.6777009,0.00005043895,0.00008227616,0.0017327,0.0004063427,0.00002841349,0.3144352,0.0006231652,0.0002185248,0.0001674008],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988274,0.000275343,0.0004221718,0.0001451664,0.000166745,0.0001014968,0.00003032762,0.000005494138,0.00002585449],"genre_scores_gemma":[0.9964116,0.0001135984,0.002738497,0.0001591405,0.000487543,0.000007563242,0.000007082345,0.00001766175,0.0000573058],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6788033,"threshold_uncertainty_score":0.6312816,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01012897468556583,"score_gpt":0.2204641995735566,"score_spread":0.2103352248879908,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}