{"id":"W2076280550","doi":"10.1152/ajpgi.00054.2011","title":"Polyamines mediate glutamine-dependent induction of the intestinal epithelial heat shock response","year":2011,"lang":"en","type":"article","venue":"American Journal of Physiology-Gastrointestinal and Liver Physiology","topic":"Polyamine Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute","keywords":"Spermidine; Ornithine decarboxylase; Glutamine; Spermine; Polyamine; Putrescine; Biology; Heat shock protein; Hsp70; Biochemistry; Heat shock; Ornithine decarboxylase antizyme; Ornithine; Cell biology; Molecular biology; Enzyme; Arginine; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001063985,0.0004387439,0.0003386321,0.0001580186,0.0000998365,0.000228584,0.0001845316,0.0002283779,0.001175224],"category_scores_gemma":[0.00009359575,0.0001415032,0.0003634291,0.0001131781,0.0001557729,0.0002116937,0.0002810926,0.0004211587,0.0003451178],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002156465,"about_ca_system_score_gemma":0.0001243115,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007300263,"about_ca_topic_score_gemma":0.001055614,"domain_scores_codex":[0.9998821,0.00002147202,0.00001153368,0.00002486768,0.00002244382,0.00003755448],"domain_scores_gemma":[0.9998865,0.00001252923,0.00002430437,0.00001293599,0.00002212373,0.00004154784],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001173073,0.00001183033,0.00008942161,0.00003158928,0.000003383385,0.00002865693,0.000009767003,0.000008473105,0.9992433,0.00001273974,0.00001370683,0.0004299099],"study_design_scores_gemma":[0.0000239132,0.0004144564,0.01724567,0.000008754075,0.00001655947,0.0001067001,0.00004292914,0.0003227017,0.979903,0.00002629547,0.001883651,0.000005237881],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924405,0.004076095,0.001864678,0.00006201684,0.00004445487,0.00003512734,0.0003236485,0.00007503287,0.001078338],"genre_scores_gemma":[0.9934596,0.001697383,0.00135213,0.00006109434,0.00001975993,0.00003094971,0.0006820563,0.00001701912,0.00268009],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001175224,"threshold_uncertainty_score":0.003931522,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01012897468556583,"score_gpt":0.2204641995735566,"score_spread":0.2103352248879908,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}