{"id":"W2076294911","doi":"10.1159/000216259","title":"Thrombin Inhibition by Hirudin: How Hirudin Inhibits Thrombin","year":2009,"lang":"en","type":"review","venue":"Haemostasis","topic":"Heparin-Induced Thrombocytopenia and Thrombosis","field":"Medicine","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Canadian Red Cross Society","funders":"National Heart, Lung, and Blood Institute","keywords":"Hirudin; Thrombin; Chemistry; Antithrombin; Prothrombinase; Fibrin; Binding site; Biophysics; Fibrinogen; Biochemistry; Heparin; Stereochemistry; Platelet; Immunology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003672283,0.0007989141,0.00119203,0.001620218,0.0002311284,0.0007341358,0.000891845,0.0008304201,0.001990288],"category_scores_gemma":[0.0003426173,0.0003311627,0.0003514914,0.001707407,0.0004127365,0.000979795,0.0004244773,0.001049342,0.002729676],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004893682,"about_ca_system_score_gemma":0.0003714047,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008244911,"about_ca_topic_score_gemma":0.001187642,"domain_scores_codex":[0.9998502,0.00002135937,0.00001808019,0.00002778062,0.00006613541,0.0000163723],"domain_scores_gemma":[0.9999092,0.00003220617,0.00001462055,0.000004976146,0.00002874283,0.00001031281],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001199871,0.00008747257,0.0002053354,0.01138846,0.0001066187,0.0003575482,0.00007333422,0.0005196288,0.01001988,0.003658543,0.02254161,0.9509216],"study_design_scores_gemma":[0.00003373017,0.0001237407,0.001147887,0.0008979619,0.00008046791,0.001455015,0.00003270846,0.0001624361,0.003026474,0.001493603,0.991525,0.00002100984],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003808961,0.9972921,0.0002301079,0.0001521025,0.000205105,0.000006471243,0.00001618751,0.00001387198,0.001703183],"genre_scores_gemma":[0.002440229,0.9954118,0.0002704406,0.0001668205,0.0001560617,0.00001180163,0.00003898024,0.000003293096,0.00150055],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001990288,"threshold_uncertainty_score":0.006658196,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1074893598183782,"score_gpt":0.3657996010848943,"score_spread":0.2583102412665161,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}