{"id":"W2076302459","doi":"10.1159/000322330","title":"The Transcription Factors NFAT and CREB Have Different Susceptibilities to the Reduced Ca<sup>2+</sup> Responses Caused by the Knock Down of Inositol Trisphosphate Receptor in HEK 293A Cells","year":2010,"lang":"en","type":"article","venue":"Cellular Physiology and Biochemistry","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"NFAT; CREB; HEK 293 cells; Chemistry; Cell biology; Transcription factor; Gene isoform; Intracellular; Inositol; Receptor; Molecular biology; Biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001827311,0.0004908354,0.0005215236,0.0002858573,0.0002215667,0.0004569151,0.0003299875,0.0004277485,0.002845451],"category_scores_gemma":[0.000154413,0.0002319879,0.0006917423,0.0002690546,0.0004827043,0.0003201413,0.000258761,0.001091641,0.001193415],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003334831,"about_ca_system_score_gemma":0.0002486401,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001070187,"about_ca_topic_score_gemma":0.0009463861,"domain_scores_codex":[0.9996384,0.00002231141,0.0000496759,0.00009798277,0.0001052219,0.00008628291],"domain_scores_gemma":[0.9998237,0.00003055327,0.00004651168,0.00002363104,0.00002581135,0.00004971886],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008533182,0.00001049467,0.00006441601,0.00002430141,0.000003474494,0.00002973459,0.00001017376,0.00001295113,0.9994434,0.00003016131,0.00002144381,0.0002642077],"study_design_scores_gemma":[0.00001854856,0.00007196592,0.002930206,0.000004821504,0.00001884186,0.0003026774,0.00003099585,0.000380583,0.9937969,0.00003387988,0.002402712,0.000007751882],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9790645,0.002470321,0.01168699,0.0003627504,0.0001754158,0.0000623706,0.003440538,0.0003941808,0.00234307],"genre_scores_gemma":[0.9706062,0.001676469,0.00915453,0.0002209242,0.00003835343,0.0002300416,0.007411482,0.0002287356,0.01043332],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002845451,"threshold_uncertainty_score":0.009518921,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006681385729973319,"score_gpt":0.2141068198321684,"score_spread":0.2074254341021951,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}