{"id":"W2076302459","doi":"10.1159/000322330","title":"The Transcription Factors NFAT and CREB Have Different Susceptibilities to the Reduced Ca<sup>2+</sup> Responses Caused by the Knock Down of Inositol Trisphosphate Receptor in HEK 293A Cells","year":2010,"lang":"en","type":"article","venue":"Cellular Physiology and Biochemistry","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"NFAT; CREB; HEK 293 cells; Chemistry; Cell biology; Transcription factor; Gene isoform; Intracellular; Inositol; Receptor; Molecular biology; Biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003553468,0.000302893,0.0002697253,0.00002620512,0.0003566929,0.00004132352,0.0002906619,0.0003614733,0.00003779937],"category_scores_gemma":[0.0001142371,0.0001698197,0.0001162726,0.00008458944,0.0006584263,0.000006975536,0.0001171677,0.000300338,0.000001422925],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001421408,"about_ca_system_score_gemma":0.00005809113,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003513162,"about_ca_topic_score_gemma":0.00005396765,"domain_scores_codex":[0.9984038,0.0002514435,0.0003686344,0.0005031432,0.0001360197,0.0003369608],"domain_scores_gemma":[0.9989951,0.0001387526,0.0001426965,0.0005362739,0.00007943896,0.0001077628],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004512104,0.00006076599,0.0003089179,0.00005819689,0.00004659993,6.490913e-7,0.0004539729,0.00001220559,0.9971116,0.00001924836,0.001106813,0.0003697897],"study_design_scores_gemma":[0.0005526567,0.0001386441,0.001903975,0.00002599116,0.00002900639,0.000003336462,0.0006644446,0.00009581727,0.9891318,0.00005762214,0.007176037,0.0002206507],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951221,0.003477211,0.0000246769,0.0006143965,0.0001345251,0.0004624579,0.0001362469,0.000009426712,0.00001900365],"genre_scores_gemma":[0.9978718,0.0004514885,0.00002013692,0.00009241279,0.0001432939,0.0000552944,0.0002473059,0.00001916648,0.001099082],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007979812,"threshold_uncertainty_score":0.6925048,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006681385729973319,"score_gpt":0.2141068198321684,"score_spread":0.2074254341021951,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}