{"id":"W2076308802","doi":"10.1128/aac.00926-08","title":"Relative Contributions of the <i>Candida albicans</i> ABC Transporters Cdr1p and Cdr2p to Clinical Azole Resistance","year":2009,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":126,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University; Institute for Research in Immunology and Cancer","funders":"Canadian Institutes of Health Research","keywords":"Azole; Candida albicans; ATP-binding cassette transporter; Biology; Ketoconazole; Corpus albicans; Itraconazole; Microbiology; Gene; Fluconazole; Heterologous expression; Drug resistance; Genetics; Transporter; Antifungal; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002292307,0.0004006628,0.0003946345,0.0003395037,0.000135384,0.0006355098,0.0002602428,0.0003501317,0.0008835643],"category_scores_gemma":[0.0004152696,0.0002015354,0.0002177999,0.0002163377,0.0002824953,0.000217107,0.0002580096,0.0007183665,0.0002100192],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003544656,"about_ca_system_score_gemma":0.000268824,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007061677,"about_ca_topic_score_gemma":0.0006096337,"domain_scores_codex":[0.9996401,0.00007005844,0.00005029555,0.00006225128,0.0001095767,0.0000676616],"domain_scores_gemma":[0.9996992,0.00007504514,0.00006000709,0.00002904804,0.00005727527,0.00007929098],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002577139,0.0000283885,0.001171597,0.00003181454,0.000009543534,0.0000591124,0.000008628708,0.00006904609,0.9965194,0.00005086185,0.00002609915,0.001767782],"study_design_scores_gemma":[0.00003291882,0.0003982483,0.02860188,0.000009873977,0.0001075197,0.001016164,0.00006457749,0.001181583,0.9670158,0.00005825538,0.00150327,0.000009679581],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970071,0.001425598,0.0005974803,0.00009676279,0.000008784314,0.00001187355,0.0001816853,0.00002267103,0.0006480922],"genre_scores_gemma":[0.9972396,0.0005763067,0.001037376,0.00007189685,0.00001520702,0.00001478359,0.000600345,0.00001435457,0.0004301202],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008835643,"threshold_uncertainty_score":0.002955794,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01210336530590646,"score_gpt":0.3104350919834911,"score_spread":0.2983317266775847,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}