{"id":"W2076312582","doi":"10.1038/nbt.2328","title":"Directed differentiation of human pluripotent stem cells into mature airway epithelia expressing functional CFTR protein","year":2012,"lang":"en","type":"article","venue":"Nature Biotechnology","topic":"Neonatal Respiratory Health Research","field":"Medicine","cited_by":433,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Stem Cell Network; Hospital for Sick Children","funders":"Canadian Institutes of Health Research","keywords":"Induced pluripotent stem cell; Cystic fibrosis; Cell biology; Cystic fibrosis transmembrane conductance regulator; Stem cell; Biology; Cellular differentiation; Directed differentiation; Embryonic stem cell; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004811188,0.0002086506,0.000172899,0.0002362193,0.0001201299,0.0002953249,0.000157837,0.0002873263,0.001639068],"category_scores_gemma":[0.0002383894,0.000190236,0.0002741017,0.0001912428,0.000154034,0.0001327057,0.0002403892,0.0006328706,0.0006124726],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001214303,"about_ca_system_score_gemma":0.0002025021,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002326243,"about_ca_topic_score_gemma":0.0005193655,"domain_scores_codex":[0.9998416,0.00002716038,0.00003217783,0.00002760973,0.00004299493,0.00002843743],"domain_scores_gemma":[0.9998395,0.00005064519,0.00002455573,0.00002273441,0.0000350215,0.00002745923],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000591852,0.000016049,0.0001334653,0.00003038474,0.000005419438,0.00005829195,0.00003217027,0.0001078893,0.9973499,0.0003382041,0.00008116387,0.001787761],"study_design_scores_gemma":[0.00003843077,0.0001855137,0.001416024,0.00001010022,0.00002402497,0.0002270361,0.00002312286,0.0009628207,0.9905508,0.0001235661,0.00643474,0.00000396351],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9545233,0.001786693,0.03327953,0.0002401938,0.0001964623,0.0003970355,0.002259029,0.0001893963,0.007128278],"genre_scores_gemma":[0.9737275,0.001071472,0.01460169,0.0002052117,0.00003046452,0.0001346544,0.002335608,0.00006225499,0.007831132],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001639068,"threshold_uncertainty_score":0.00548321,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02218517385719583,"score_gpt":0.3126940323285715,"score_spread":0.2905088584713757,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}