{"id":"W2076313803","doi":"10.1038/nrg2680","title":"Genetics of motor neuron disorders: new insights into pathogenic mechanisms","year":2009,"lang":"en","type":"review","venue":"Nature Reviews Genetics","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":311,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Canadian Institutes of Health Research; Health Canada; ALS Society of Canada; Muscular Dystrophy Association; ALS Association","keywords":"Amyotrophic lateral sclerosis; Biology; Hereditary spastic paraplegia; SOD1; Neuroscience; Motor neuron; Genetics; Gene; Phenotype; Candidate gene; Disease; Medicine; Mutant; Pathology; Spinal cord","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.0004508247,0.001130093,0.005036066,0.0004737903,0.00008182042,0.00004153978,0.001064074,0.002389377,0.0001661464],"category_scores_gemma":[0.0003804953,0.000772159,0.001914569,0.001250098,0.0001152421,0.00004264387,0.0003606689,0.002981382,0.0002092994],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002927832,"about_ca_system_score_gemma":0.001101879,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000911217,"about_ca_topic_score_gemma":0.00002428248,"domain_scores_codex":[0.9939846,0.0007166443,0.002180653,0.00113822,0.001255985,0.0007239254],"domain_scores_gemma":[0.9957676,0.0001291211,0.001069236,0.002097228,0.0002390753,0.0006977225],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001341659,0.0001412469,0.000001360226,0.02384402,0.000133016,0.00001874821,0.00003937391,5.035103e-7,0.0004429609,0.000107318,0.001807122,0.9734509],"study_design_scores_gemma":[0.0004440775,0.001105973,0.0001148889,0.01998777,0.002177098,0.00004629,0.000001178216,0.00001828621,0.00001810584,0.001077903,0.9744301,0.0005783642],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00001885189,0.9930047,0.0004053767,0.000154314,0.0004396537,0.005655873,0.00001937159,0.00005152712,0.0002503697],"genre_scores_gemma":[0.00001914027,0.9785081,0.01879712,0.0003953312,0.0008413144,0.00009519238,0.0002151483,0.0002107657,0.0009179307],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9728726,"threshold_uncertainty_score":0.9994729,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04889509934949401,"score_gpt":0.3678268459475096,"score_spread":0.3189317465980156,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}