{"id":"W2076324093","doi":"10.1016/s1525-0016(03)00068-6","title":"Hammerhead ribozyme-mediated destruction of nuclear foci in myotonic dystrophy myoblasts","year":2003,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Myotonic dystrophy; Biology; Molecular biology; Ribozyme; Untranslated region; Mammalian CPEB3 ribozyme; Hammerhead ribozyme; Mutant; Messenger RNA; Gene isoform; Three prime untranslated region; Trinucleotide repeat expansion; Gene; Cell biology; RNA; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008194426,0.0001893579,0.0002020552,0.0001547746,0.00005332405,0.00002278654,0.0002036382,0.00006234486,0.0001251578],"category_scores_gemma":[0.0002502624,0.000189134,0.00009945037,0.0005006255,0.0001442461,0.00006299764,0.00001817711,0.0001267662,0.00005016707],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003389977,"about_ca_system_score_gemma":0.00006109931,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001255331,"about_ca_topic_score_gemma":0.000002615047,"domain_scores_codex":[0.998185,0.0004913082,0.0002703488,0.0004439578,0.0003087363,0.0003006158],"domain_scores_gemma":[0.9993464,0.00005382855,0.0001088438,0.0003613431,0.00004229333,0.00008727609],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006565989,0.0001629621,0.0006733637,0.00000563533,0.000005190785,0.00003866687,0.00009935768,0.0004782046,0.9954433,0.002264967,0.00001656231,0.0007461113],"study_design_scores_gemma":[0.001147029,0.0002390489,0.005415472,0.0000100522,0.000003613732,0.00001003855,0.00002105053,0.0001653312,0.9909351,0.0007530617,0.0011411,0.000159076],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983271,0.0002190349,0.0002642724,0.00008762151,0.0001457738,0.0003506128,0.00001048591,0.00003849488,0.0005565454],"genre_scores_gemma":[0.9986081,0.0001539075,0.0004034189,0.0007327045,0.000008075185,0.0000236268,0.000002385648,0.00004623736,0.00002158311],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004742109,"threshold_uncertainty_score":0.771266,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01746096818133441,"score_gpt":0.2432060226704005,"score_spread":0.2257450544890661,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}