{"id":"W2076353778","doi":"10.1016/j.bmcl.2011.09.012","title":"A fluorescent probe for GM1 gangliosidosis related β-galactosidase: N-(Dansylamino)hexylaminocarbonylpentyl-1,5-dideoxy-1,5-imino-d-galactitol","year":2011,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Galactitol; Chemistry; Fluorescence; Mutant; Biochemistry; Stereochemistry; Galactose","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002734846,0.0006019725,0.0003275425,0.000492985,0.0003834158,0.0003460782,0.0006043668,0.0006757756,0.001805569],"category_scores_gemma":[0.0002155559,0.0002746465,0.0002473883,0.0003976206,0.0004109931,0.0003648785,0.000362083,0.0009177134,0.0009641489],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007538361,"about_ca_system_score_gemma":0.0004082209,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006597071,"about_ca_topic_score_gemma":0.0005653118,"domain_scores_codex":[0.999848,0.00003441211,0.000007930425,0.00003461371,0.00002796354,0.00004690565],"domain_scores_gemma":[0.9998482,0.0000528192,0.00002349905,0.00001984861,0.00001777356,0.00003783431],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009027209,0.0000167758,0.00006405115,0.00005928477,0.00000381869,0.00009992143,0.00003078943,0.0000804533,0.9963618,0.0009592559,0.0001457932,0.002087817],"study_design_scores_gemma":[0.00001662188,0.00009576228,0.0005246903,0.000006868403,0.00001119414,0.0005344077,0.00001889794,0.0005926199,0.9927173,0.0001101858,0.005365534,0.000005885062],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8721694,0.005167346,0.09771349,0.001284931,0.0002510273,0.0002547995,0.001222906,0.0009582953,0.02097788],"genre_scores_gemma":[0.9313909,0.003286386,0.05294896,0.0003534586,0.00006927068,0.0002132906,0.002030788,0.0001019098,0.009605073],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001805569,"threshold_uncertainty_score":0.006040275,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02190400110331787,"score_gpt":0.2390279318560831,"score_spread":0.2171239307527652,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}