{"id":"W2076363741","doi":"10.1016/j.radonc.2009.06.021","title":"Binding of cetuximab to the EGFRvIII deletion mutant and its biological consequences in malignant glioma cells","year":2009,"lang":"en","type":"article","venue":"Radiotherapy and Oncology","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"KWF Kankerbestrijding","keywords":"Cetuximab; Internalization; Glioma; Flow cytometry; Cancer research; Epidermal growth factor receptor; Chemistry; Radiosensitivity; Clonogenic assay; Cell culture; Downregulation and upregulation; Cell; Biology; Molecular biology; Receptor; Antibody; Monoclonal antibody; Immunology; Medicine; Radiation therapy; Internal medicine; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002300419,0.0002448133,0.0004731769,0.0003073285,0.0003724534,0.0003397393,0.0004015206,0.0005946666,0.002563258],"category_scores_gemma":[0.0002663252,0.0003279874,0.0004286528,0.0004050601,0.00024644,0.0002233744,0.0001461471,0.0005757558,0.0005087684],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006540377,"about_ca_system_score_gemma":0.0003886624,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01570786,"about_ca_topic_score_gemma":0.0096906,"domain_scores_codex":[0.9996107,0.0000916273,0.00002423433,0.00003319413,0.0001075131,0.0001327978],"domain_scores_gemma":[0.9998816,0.00004594963,0.000009764392,0.0000197213,0.0000208339,0.0000220714],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001478913,0.0002129985,0.000562488,0.00006398376,0.00002999042,0.0002963502,0.00008082669,0.0006719156,0.9947365,0.0002312844,0.0002429197,0.001391725],"study_design_scores_gemma":[0.0000893414,0.001164058,0.02231018,0.000007912459,0.00003830065,0.0007159568,0.0001811927,0.004221987,0.9691263,0.00007618577,0.002049737,0.00001889608],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969456,0.0007555119,0.0003083197,0.0001023261,0.00002928346,0.00001237119,0.0003049114,0.00001854385,0.001523231],"genre_scores_gemma":[0.9963382,0.0003138732,0.0002698953,0.00004305506,0.000006100802,0.00001201246,0.0006962981,0.000007377874,0.002313234],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01570786,"threshold_uncertainty_score":0.03123283,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05783316915741105,"score_gpt":0.3816602847716133,"score_spread":0.3238271156142023,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}