{"id":"W2076363741","doi":"10.1016/j.radonc.2009.06.021","title":"Binding of cetuximab to the EGFRvIII deletion mutant and its biological consequences in malignant glioma cells","year":2009,"lang":"en","type":"article","venue":"Radiotherapy and Oncology","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"KWF Kankerbestrijding","keywords":"Cetuximab; Internalization; Glioma; Flow cytometry; Cancer research; Epidermal growth factor receptor; Chemistry; Radiosensitivity; Clonogenic assay; Cell culture; Downregulation and upregulation; Cell; Biology; Molecular biology; Receptor; Antibody; Monoclonal antibody; Immunology; Medicine; Radiation therapy; Internal medicine; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006935653,0.00009256386,0.0003391998,0.0001526401,0.00004975536,0.00000777612,0.00008086649,0.0001436834,0.00008865328],"category_scores_gemma":[0.00005405191,0.00005507378,0.00002423763,0.00026303,0.0001958889,0.00002070316,0.00001455366,0.0001627359,0.000002707773],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001903078,"about_ca_system_score_gemma":0.0001417915,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005069202,"about_ca_topic_score_gemma":0.00006540632,"domain_scores_codex":[0.9989789,0.0001983986,0.0002303225,0.0002234312,0.0001188525,0.0002500647],"domain_scores_gemma":[0.9995058,0.0002094697,0.00004970015,0.0001025854,0.00003577334,0.00009665518],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006291758,0.0001165891,0.002724529,0.00002001278,0.00001591064,0.0001969486,0.0009894752,0.000004536699,0.934299,0.0007865148,0.0001556963,0.06006164],"study_design_scores_gemma":[0.01083877,0.03496573,0.06162721,0.0005091001,0.00004407245,0.002831031,0.001646022,0.001573876,0.7679948,0.0009442217,0.1165498,0.0004753393],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9790533,0.004873624,0.00005935259,0.01516203,0.00007496083,0.0005120493,0.000006212439,0.00001001371,0.0002484711],"genre_scores_gemma":[0.9919652,0.005920541,0.0005379342,0.001432927,0.00008716954,0.00001761102,0.000001283724,0.000005310861,0.00003198394],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1663041,"threshold_uncertainty_score":0.2245844,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05783316915741105,"score_gpt":0.3816602847716133,"score_spread":0.3238271156142023,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}