{"id":"W2076379671","doi":"10.1371/journal.pone.0030229","title":"Ex Vivo Expansion of Human CD8+ T Cells Using Autologous CD4+ T Cell Help","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; University of Toronto","funders":"National Cancer Institute; American Society of Hematology; National Institutes of Health; Cancer Research Institute","keywords":"T cell; CD8; Cytotoxic T cell; Biology; Cell biology; IL-2 receptor; FOXP3; Antigen-presenting cell; Interleukin 21; Immune system; Immunology; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002077208,0.0005323112,0.0002161315,0.0002124881,0.00009534488,0.000341194,0.00021105,0.0003759764,0.001379579],"category_scores_gemma":[0.0001081193,0.0000945292,0.0002356868,0.0001208256,0.0001620404,0.0001691878,0.0002624254,0.0007422486,0.0005800909],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001271857,"about_ca_system_score_gemma":0.0001561297,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009099925,"about_ca_topic_score_gemma":0.0001400656,"domain_scores_codex":[0.9998158,0.00003830198,0.00002220401,0.00004725371,0.00004543396,0.00003111385],"domain_scores_gemma":[0.9998807,0.00003063387,0.00002456705,0.00002109463,0.00001093688,0.00003206507],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001359151,0.0001250983,0.0002271236,0.00008256642,0.000006061847,0.00006620556,0.00001759839,0.0002791229,0.9960999,0.0000700368,0.00007069563,0.002819653],"study_design_scores_gemma":[0.00005451754,0.0007132306,0.0008222546,0.00001139064,0.00003422364,0.0003821017,0.000007675746,0.001345017,0.992783,0.00003515676,0.003807942,0.00000356923],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.970396,0.002719499,0.02276627,0.0001344131,0.0001039347,0.0002032514,0.0004084829,0.00026964,0.002998487],"genre_scores_gemma":[0.9805233,0.001068297,0.01582363,0.00007054722,0.00006539783,0.0001172699,0.0005642631,0.0000344858,0.001732938],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001379579,"threshold_uncertainty_score":0.004615128,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1094466641069173,"score_gpt":0.323557040482938,"score_spread":0.2141103763760207,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}