{"id":"W2076423158","doi":"10.1038/sj.bjc.6600168","title":"Circadian optimisation of irinotecan and oxaliplatin efficacy in mice with Glasgow osteosarcoma","year":2002,"lang":"en","type":"article","venue":"British Journal of Cancer","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Cancer Research","keywords":"Oxaliplatin; Irinotecan; Tolerability; Medicine; Circadian rhythm; Chemotherapy; Camptothecin; Internal medicine; Anesthesia; Adverse effect; Colorectal cancer; Cancer; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009490146,0.00006330859,0.0001331031,0.00004141876,0.00001956836,0.00001833797,0.00007186387,0.00005739468,0.00004472407],"category_scores_gemma":[0.000009633181,0.00006860027,0.00003399815,0.00006134521,0.00004259749,0.000005878871,0.00001316377,0.00008788326,1.337415e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000189758,"about_ca_system_score_gemma":0.00004359483,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002636325,"about_ca_topic_score_gemma":0.001906089,"domain_scores_codex":[0.9994584,0.00002242737,0.0002069237,0.00009736103,0.0001063768,0.0001084493],"domain_scores_gemma":[0.9996223,0.000006405203,0.0001718404,0.00005450964,0.00008813803,0.00005677887],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002042993,0.0001430856,0.001910045,0.00003302891,0.00008786314,0.00005053187,0.0002287067,0.0004622356,0.4830844,0.00003157663,0.0001518501,0.5136124],"study_design_scores_gemma":[0.01136908,0.002935937,0.07577725,0.001154555,0.0001393954,0.002715798,0.0003123569,0.0003238509,0.842696,0.0001194663,0.06189018,0.0005661831],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9854304,0.0138824,0.0001621973,0.0001636694,0.00006609136,0.00006894216,0.00001271285,9.170748e-7,0.0002126628],"genre_scores_gemma":[0.9930398,0.005932485,0.0006697156,0.0001238795,0.0001193626,0.000002682642,0.000002048429,0.00001195486,0.00009805302],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5130462,"threshold_uncertainty_score":0.2797438,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.011768452023315,"score_gpt":0.2397905785101323,"score_spread":0.2280221264868173,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}