{"id":"W2076433016","doi":"10.1242/jcs.087395","title":"Cadherin Point Mutations Alter Cell Sorting and Modulate GTPase Signaling","year":2012,"lang":"en","type":"article","venue":"Journal of Cell Science","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Heart, Lung, and Blood Institute; McMaster University","keywords":"Biology; Cadherin; Cell biology; Point mutation; GTPase; Sorting; Signal transduction; Cell; Genetics; Mutation; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001117416,0.0000834587,0.00009661828,0.00006958978,0.0001673769,0.00004866574,0.0001603742,0.00004201761,0.00001298785],"category_scores_gemma":[0.00007425505,0.00006852943,0.00005486904,0.0001212566,0.0001425009,0.00002981303,0.00005583349,0.0001108151,0.00000460328],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001328023,"about_ca_system_score_gemma":0.0001190467,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004521107,"about_ca_topic_score_gemma":5.69191e-7,"domain_scores_codex":[0.9990789,0.00003273748,0.0002665363,0.0001267106,0.0002147753,0.0002803411],"domain_scores_gemma":[0.9992642,0.00001512482,0.0002484081,0.0001035009,0.0001388914,0.0002298141],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00000785986,0.00003809227,0.001000018,0.000008776985,0.000002628847,0.000003950901,0.0003760657,0.001011279,0.9970906,0.000006900825,0.00001174979,0.0004420369],"study_design_scores_gemma":[0.0002157285,0.0001374016,0.0002879019,0.00001458306,0.00001290349,0.00006617027,0.0002344531,0.0004056149,0.9980195,0.0000879885,0.0004218688,0.00009584017],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993978,0.0007614659,0.004021282,0.00005732159,0.0001815852,0.00003383744,0.000001179119,0.000002473812,0.000962869],"genre_scores_gemma":[0.994021,0.00003762816,0.005386801,0.0001037028,0.0002566472,5.881512e-7,8.214128e-7,0.000007545348,0.0001852401],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001365519,"threshold_uncertainty_score":0.2794549,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01124161936818744,"score_gpt":0.2508742538494328,"score_spread":0.2396326344812454,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}