{"id":"W2076441335","doi":"10.1038/cgt.2008.94","title":"Transgene expression of α tumor necrosis factor with mutations D142N and A144R under control of human telomerase reverse transcriptase promoter eradicates well-established tumors and induces long-term antitumor immunity","year":2008,"lang":"en","type":"article","venue":"Cancer Gene Therapy","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Saskatchewan Cancer Agency; University of Saskatchewan","funders":"","keywords":"Telomerase reverse transcriptase; Telomerase; Transgene; Reverse transcriptase; Biology; Cancer research; Immunity; Molecular biology; Virology; Promoter; Mutation; Gene; Gene expression; RNA; Immunology; Genetics; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001903687,0.000481411,0.0003450796,0.0004724487,0.0001627083,0.0003138381,0.0002798164,0.0003532236,0.001119663],"category_scores_gemma":[0.000133835,0.0001973671,0.0003481507,0.0002388207,0.0003745352,0.0002219071,0.0001854592,0.0009202781,0.0005871847],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003979857,"about_ca_system_score_gemma":0.0002844477,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005280222,"about_ca_topic_score_gemma":0.0006368807,"domain_scores_codex":[0.999769,0.0000264458,0.00002883505,0.0000531114,0.00006660658,0.00005597455],"domain_scores_gemma":[0.9997812,0.00003454973,0.00008078147,0.00003745898,0.00001588208,0.00005018152],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008573654,0.00003334602,0.00006993723,0.000005452977,0.000003654638,0.00002543302,0.00000475012,0.00004126151,0.9992018,0.00009726523,0.00002437656,0.0004068588],"study_design_scores_gemma":[0.00003267281,0.0002158473,0.0004824404,0.00000185771,0.00001132875,0.0001679772,0.000007046011,0.0006115514,0.9974425,0.0000411695,0.0009828671,0.000002676638],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924891,0.0005685858,0.004681897,0.0001124603,0.00008507426,0.00005662522,0.0003486242,0.0002142108,0.001443514],"genre_scores_gemma":[0.9919979,0.0003722687,0.003163101,0.00004002441,0.0000251194,0.00004493782,0.0005457897,0.00005970984,0.003751337],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001119663,"threshold_uncertainty_score":0.003745675,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02323944122611877,"score_gpt":0.2658059489375001,"score_spread":0.2425665077113814,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}