{"id":"W2076441335","doi":"10.1038/cgt.2008.94","title":"Transgene expression of α tumor necrosis factor with mutations D142N and A144R under control of human telomerase reverse transcriptase promoter eradicates well-established tumors and induces long-term antitumor immunity","year":2008,"lang":"en","type":"article","venue":"Cancer Gene Therapy","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Saskatchewan Cancer Agency; University of Saskatchewan","funders":"","keywords":"Telomerase reverse transcriptase; Telomerase; Transgene; Reverse transcriptase; Biology; Cancer research; Immunity; Molecular biology; Virology; Promoter; Mutation; Gene; Gene expression; RNA; Immunology; Genetics; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006094968,0.0002106287,0.0003127575,0.00007454912,0.0001358839,0.00001342946,0.0001373753,0.00007340893,0.00007847995],"category_scores_gemma":[0.000003056506,0.0001648025,0.00006352135,0.0000874438,0.000408248,0.00002446034,0.00001295204,0.00008976451,1.877389e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008407645,"about_ca_system_score_gemma":0.0001072888,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002985058,"about_ca_topic_score_gemma":0.00005482498,"domain_scores_codex":[0.9990461,0.00007613705,0.0002797635,0.0003052838,0.0001144492,0.0001782828],"domain_scores_gemma":[0.9993546,0.00001018481,0.000161812,0.0002567573,0.0001260696,0.00009058805],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006501877,0.0001443461,0.04139946,0.00005081488,0.000113831,0.000007887529,0.0007992537,0.00001527477,0.9562999,8.109682e-7,0.00002790502,0.0004902988],"study_design_scores_gemma":[0.002277659,0.0008658565,0.1486983,0.00007790374,0.00003140322,0.00002525548,0.0001068093,0.000003072386,0.8477211,0.00000769195,0.00001165715,0.0001732691],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941281,0.004864513,0.0002916775,0.00007128235,0.00003124853,0.0003679275,0.000231271,0.000007263597,0.000006723553],"genre_scores_gemma":[0.9957915,0.003692683,0.0001002034,0.0001642881,0.00003667197,0.00005280858,0.00008747424,0.00002458806,0.00004977393],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1085788,"threshold_uncertainty_score":0.6720453,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02323944122611877,"score_gpt":0.2658059489375001,"score_spread":0.2425665077113814,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}